Decoding the DNA methylome of central nervous system tumors: An emerging modality for integrated diagnosis
Kaishi Satomi,
Koichi Ichimura,
Junji Shibahara
Abstract:The definitive diagnosis and classification of individual cancers are crucial for patient care and cancer research. To achieve a robust diagnosis of central nervous system (CNS) tumors, a genotype‐phenotype integrated diagnostic approach was introduced in recent versions of the World Health Organization classification, followed by the incorporation of a genome‐wide DNA methylome‐based classification. Microarray‐based platforms are widely used to obtain DNA methylome data, and the German Cancer Research Center … Show more
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