Decoding the chemical composition and pharmacological mechanisms of Jiedu Tongluo Tiaogan Formula using high-performance liquid chromatography coupled with network pharmacology-based investigation

Zhang, Qi; Piao, Chunli; Jin, Wenqi; Jin, De; Wang, Han; Tang, Cheng; Zhao, Xiaohua; Zhang, Naiwen; Gao, Shengnan; Lian, Fengmei

doi:10.18632/aging.203679

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…Licorice: heart, lung, spleen, stomach meridian. Tonifying spleen and Qi, clearing heat and detoxifying, expectorating cough, relieving pain and relieving pain, harmonizing various medicines[ 22 ]. The effect of the whole prescription to play together in Fuzheng, collaterals and detoxification[ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Yin,

Yao,

et al. 2024

World J Clin Cases

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BACKGROUND Oral cancer, which is caused by mucous membrane variation, represents a prevalent malignant tumor in the oral and maxillofacial region, posing a significant threat to patients’ lives and safety. While surgical intervention stands as a cornerstone treatment for oral cancer patients, it carries the risk of incomplete treatment or high rates of postoperative recurrence. Hence, a multifaceted approach incorporating diverse treatment modalities is essential to enhance patient prognosis. AIM To analyze the application effect of Tongluo Jiedu prescription as adjuvant therapy and its influence on patient prognosis in patients with oral cancer. METHODS Eighty oral cancer patients in our hospital were selected and divided into the observation group and control group by a random number table. The control group was treated with continuous arterial infusion chemotherapy of cisplatin and 5-fluorouracil. The observation group was additionally given Tongluo Jiadu prescription. The inflammatory stress level, peripheral blood T-cell subsets, and immune function of the two groups were subsequently observed. SPSS 21.0 was used for data analysis. RESULTS The observation group demonstrated lower levels of interleukin-6 and C-reactive protein, and a higher level of tumor necrosis factor in comparison to the control group. After treatment, the immune function in the observation group was significantly better than in the control group. CONCLUSION Tongluo Jiedu prescription can improve the immune function and oxidative stress level of patients with oral cancer and accelerate the recovery process.

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Section: Discussionmentioning

confidence: 99%

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Yin,

Yao,

et al. 2024

World J Clin Cases

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“…Chinese herbal compounds could inhibit the progression of diabetes. Zhang et al found that Jiedu Tongluo Tiaogan formula (JDTL) could alleviate the progression of type 2 diabetes mellitus [ 16 ]; Yu et al suggested that Bushen Huoxue prescriptions could inhibit the development of diabetic retinopathy [ 17 ]. Meanwhile, XTZK was found to exert an antidiabetic effect [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Xiaotangzhike Pill Attenuates the Progression of Diabetes In Vivo through the Mediation of the Akt/GSK-3β Axis

Yang

Wang

Fan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Diabetes seriously threatens the health of people. Traditional Chinese medicine has been proven to inhibit the progression of diabetes. Meanwhile, the Xiaotangzhike pill (XTZK) was known to alleviate the symptom of diabetes. Thus, this research decided to investigate the mechanism underlying the impact of XTZK in diabetes remains unexplored. Methods. To assess the impact of XTZK in diabetes, in vivo model of diabetes was constructed. The contents of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) in the rats were tested by the commercial kits. In addition, Masson and hematoxylin and eosin (H&E) staining were applied for assessing the histological changes and fibrosis in the rats, respectively. Furthermore, a western blot was applied to assess the protein levels. Results. Streptozotocin (STZ) significantly increased the levels of area under the curve (AUC), TG, TC, LDL-C, and decreased the contents of HDL-C in rats, while these phenomena were partially reversed by XTZK. In addition, STZ notably induced inflammatory infiltration and fibrosis in the liver tissues of rats, which was greatly restored by XTZK. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) in the serum of rats were notably upregulated by STZ, while the effect of STZ was markedly abolished by XTZK. Meanwhile, STZ-caused the upregulation of p-Smad2 and α-SMA in rats was restored by XTZK. Furthermore, XTZK notably inhibited the progression of Qi and Yin deficiency syndrome in diabetes through the mediation of the Akt/GSK-3β axis. Conclusion. The Xiaotangzhike pill attenuates the progression of diabetes through the mediation of the Akt/GSK-3β axis. Hence, our study might supply a novel insight into discovering new strategies against diabetes.

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“…Oral bioavailability (OB) and drug similarity (DL) are two important parameters to evaluate the absorption, distribution, metabolism, and excretion (ADME) characteristics of drugs in the human body [21]. Based on the UPLC-Q-TOF-MS/MS identification results and database screening results, we obtained 141 MCLD-active compounds using the parameters of OB and DL (Supplementary Table 2).…”

Section: Screening Of Active Compounds and Related Target Proteinsmentioning

confidence: 99%

Modified Chaishao Liujunzi Decoction inhibits bile acid-induced gastric intestinal metaplasia: from network prediction to experimental verification

Sun,

Liu,

Deng

et al. 2023

Aging

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Modified Chaishao Liujunzi Decoction (MCLD) is a traditional Chinese medicine formula that is used mainly to improve clinical symptoms, alleviate gastric mucosal inflammation, and improve gastric mucosal lesions in patients with gastric intestinal metaplasia (GIM). GIM is considered a precancerous gastric cancer (GC) lesion (PLGC) and exploring effective intervention measures for GIM is of great importance for the prevention of GC. The purpose of this study was to reveal the potential molecular mechanism of MCLD in improving GIM induced by bile acid (BA) using network pharmacology and experimental validation. Through network pharmacology, we speculated that MCLD could act on GIM by driving the epidermal growth factor receptor (EGFR)/PI3K/ AKT/mammalian target of rapamycin (mTOR) pathway. After that, we used deoxycholic acid (DCA) to treat GES-1 cells to simulate BA-induced GIM and observed the effects of MCLD treatment. The results indicate that MCLD can significantly inhibit DCA-induced cell proliferation and down-regulate the expression of pro-inflammatory cytokines and intestinal-specific markers. At the same time, MCLD also negatively regulated the expression of genes and proteins of the EGFR/PI3K/AKT/mTOR pathway. Combination with EGFR agonists and inhibitors suggested that MCLD may improve GIM by inhibiting the EGFR/PI3K/AKT/mTOR pathway, which may be related to its inhibition of DCA-induced cell proliferation through this pathway. In conclusion, MCLD may improve BA-induced GIM through the EGFR/PI3K/AKT/mTOR pathway, as predicted by network pharmacology, and is a potential Chinese medicine prescription for the treatment or reversal of GIM.

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Decoding the chemical composition and pharmacological mechanisms of Jiedu Tongluo Tiaogan Formula using high-performance liquid chromatography coupled with network pharmacology-based investigation

Cited by 8 publications

References 52 publications

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Xiaotangzhike Pill Attenuates the Progression of Diabetes In Vivo through the Mediation of the Akt/GSK-3β Axis

Modified Chaishao Liujunzi Decoction inhibits bile acid-induced gastric intestinal metaplasia: from network prediction to experimental verification

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