Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling
Steve D Guzman,
Ahmad Abu-Mahfouz,
Carol S Davis
et al.
Abstract:Understanding neuromuscular junction (NMJ) repair mechanisms is essential for addressing degenerative neuromuscular conditions. Here, we focus on the role of muscle-resident Schwann cells in NMJ reinnervation. In youngSod1-/-mice, a model of progressive NMJ degeneration, we identified a clear NMJ ‘regenerative window’ that allowed us to define regulators of reinnervation and crossingSod1-/-mice withS100GFP-tg mice permitted visualization and analysis of Schwann cells. High-resolution imaging and single-cell RN… Show more
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