Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti-inflammatory, Anti-thrombotic, and Pro-angiogenic Activities

Abstract

Four active partition layers and ten isolates, including (5R)-and (5S)-macapyrrolidone A (1a, 1b), and four new alkaloids, (5R)-and (5S)-macapyrrolidone B (2a, 2b) and macapyrrolins D, E (3, 4), were isolated from maca (Lepidium meyenii Walp.), an indigenous food plant from Peru. Derived from the n-hexane layer, the macamide-rich fraction exhibited pro-angiogenic activity on EPC and HUVEC cells. Anti-thrombotic activity was displayed by the polar part of maca extracts (n-butanol and water layers). Both 75% methanol aq. (midlower polar part) and n-hexane (low polar part) layers, which showed signs of fatty acid content, markedly inhibited superoxide and elastase release in an anti-inflammatory assay. The 75% methanol aq. layer showed strong antiallergic activity, and macapyrrolin A (5) was found active based on β-hexosaminidase release inhibition assays and a ChemGPS-NP experiment. These valuable bioactivity results suggest that maca is a food plant with good benefits for human health.

Capnellenes from Capnella imbricata: Deciphering Their Anti-Inflammatory-Associated Chemical Features

“…By analyzing the 1 H and 13 C NMR spectra of compounds 4-7, it was determined that these molecules belonged to the capnellane-type sesquiterpenoids. The identification was made based on the spectroscopic data and a comparison with the literature references.…”

“…The IR spectrum exhibited absorption bands indicative of hydroxy (3548 cm −1 ) groups. Analysis of the 13 C NMR, DEPT, and HMQC spectra revealed that compound 3 consisted of 15 carbons (Table 4), including three methyls, three sp 3 methylenes, one sp 2 methylene, four sp 3 methines (including two oxymethines), three sp 3 quaternary carbons (including an oxygenated quaternary carbon), and one quaternary sp 2 carbon. The 1 H NMR spectrum displayed signals corresponding to three singlet methyls, five aliphatic methylenes, and two methines (Table 4).…”

“…Table 4. 1 H and 13 C NMR data for compound 3 and 1 H NMR data for ∆ 9(12) -Capnellene-2ξ,8β, 10α-triol [9].…”

“…In this study, we utilized ChemGPS-NP to establish the chemical relationships between capnellenes discussed in our present research and those mentioned in our previous publications [2] that possess anti-inflammatory activity. We mapped a total of 14 capnellene sesquiterpenes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) in a chemical space using PC score predictions from the online tool ChemGPS-NPWeb (Figure 5). Additionally, we retrieved previously disclosed inhibitors that target inflammation-related proteins iNOS from the ChEMBL online database and included them in the analysis.…”

Cationic N,S-chelate half-sandwich iridium complexes: synthesis, characterization, anticancer and antiplasmodial activity

“…The biological activity of N-heterocyclic derivatives, such as antihistaminic, antimalarial, antiviral, antiparasitic, and anticancer activity, has been well established during the past few years. [22][23][24][25] The study on N-heterocycle containing drugs consequently becomes an attractive field in chemistry owing to their vast medicinal value. Based on the efficacy of clinically approved N-heterocyclic derivatives of lansoprazole, omeprazole, and albendazole, research focusing on the medicinal use of such compounds as potent anticancer chemotherapeutic agents remains desirable.…”