Decoding microtubule detyrosination: enzyme families, structures, and functional implications
Jitske Bak,
Thijn R. Brummelkamp,
Anastassis Perrakis
Abstract:Microtubules are a major component of the cytoskeleton and can accumulate a plethora of modifications. The microtubule detyrosination cycle is one of these modifications; it involves the enzymatic removal of the C‐terminal tyrosine of α‐tubulin on assembled microtubules and the re‐ligation of tyrosine on detyrosinated tubulin dimers. This modification cycle has been implicated in cardiac disease, neuronal development, and mitotic defects. The vasohibin and microtubule‐associated tyrosine carboxypeptidase enzym… Show more
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