Decoding LncRNAs

Borkiewicz, Lidia; Kałafut, Joanna; Dudziak, Karolina; Przybyszewska-Podstawka, Alicja; Telejko, Ilona

doi:10.3390/cancers13112643

Cited by 20 publications

(8 citation statements)

References 284 publications

(316 reference statements)

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“…LncRNAs are also associated with many diseases. Disease-related lncRNAs will gain greater relevance as potential biomarkers in cancers and for personalized medicine, especially for gene therapy ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of lncRNA PCAT6 in Cancers

Wang

Chen

et al. 2021

Front. Oncol.

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Long non-coding RNA (lncRNA) PCAT6 is a member of the Prostate Cancer Associated Transcripts family of molecules. In this review, we focus on the latest studies involving PCAT6 in the diagnosis, treatment, and prognosis of malignant tumors of the digestive, respiratory, urinary, reproductive, motion, and nervous systems. PCAT6 was found to be highly expressed in gastric cancer, colon cancer, hepatocellular carcinoma, lung cancer, bladder cancer, ovarian cancer, breast cancer, cervical cancer, osteosarcoma, glioblastoma, and other tumors. PCAT6 can promote the development and progression of different types of malignant tumors through various mechanisms. Overall, these findings suggest that PCAT6 may play an increasingly vital role in the clinical assessment of these malignant tumors. It can function as an oncogene and may be used as a potential new prognostic biomarker of these tumors.

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Section: Introductionmentioning

confidence: 99%

The Role of lncRNA PCAT6 in Cancers

Wang

Chen

et al. 2021

Front. Oncol.

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“…Long noncoding RNAs (lncRNAs) are widely conserved sequences longer than 200 nucleotides without protein-coding capacity [ 9 ]. As an emerging class of regulatory RNAs, lncRNAs may participate in fundamental processes including cell cycle regulation, proliferation, apoptosis, self-renewal, metastasis and the DNA damage response through transcriptional or posttranscriptional regulation and thus give rise to diseases.…”

Section: Introductionmentioning

confidence: 99%

Detection and analysis of long noncoding RNA expression profiles related to epithelial–mesenchymal transition in keloids

Chen

Chu

2022

BioMed Eng OnLine

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Background The role of epithelial-mesenchymal transition (EMT) in the pathogenesis of keloids is currently raising increasing attention. Long noncoding RNAs (lncRNAs) govern a variety of biological processes, such as EMT, and their dysregulation is involved in many diseases including keloid disease. The aim of this study was to identify differentially expressed EMT-related lncRNAs in keloid tissues versus normal tissues and to interpret their functions. Results Eleven lncRNAs and 16 mRNAs associated with EMT were identified to have differential expression between keloid and normal skin tissues (fold change > 1.5, P < 0.05). Gene Ontology (GO) analysis showed that these differentially expressed mRNAs functioned in the extracellular matrix, protein binding, the positive regulation of cellular processes, the Set1C/COMPASS complex and histone acetyltransferase activity. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that these mRNAs are involved in pathways in cancer. The lncRNA, XLOC_000587 may promote cell proliferation and migration by enhancing the expression of ENAH, while AF268386 may facilitate the invasive growth of keloids by upregulating DDR2. Conclusions We characterized the differential expression profiles of EMT-related lncRNAs and mRNAs in keloids, which may contribute to preventing the occurrence and development of keloids by targeting the corresponding signaling pathways. These lncRNAs and mRNAs may provide biomarkers for keloid diagnosis and serve as potential targets for the treatment of this disease.

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“…LncRNAs are a class of ncRNAs that are more than 200 nucleotides in length. Related studies have suggested that lncRNAs can bind to DNA, RNA, and proteins, thus inhibiting or activating gene expression through complex biological mechanisms (Borkiewicz et al, 2021). Several studies have shown that the regulation of pyroptosis by lncRNAs is important in sepsis.…”

Section: The Role Of Long Non-coding Rnas In Pyroptosis In Sepsismentioning

confidence: 99%

Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction

Wen

Liu

Tong

et al. 2022

Front. Cell. Infect. Microbiol.

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Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death in intensive care units. The development of sepsis-associated organ dysfunction (SAOD) poses a threat to the survival of patients with sepsis. Unfortunately, the pathogenesis of sepsis and SAOD is complicated, multifactorial, and has not been completely clarified. Recently, numerous studies have demonstrated that pyroptosis, which is characterized by inflammasome and caspase activation and cell membrane pore formation, is involved in sepsis. Unlike apoptosis, pyroptosis is a pro-inflammatory form of programmed cell death that participates in the regulation of immunity and inflammation. Related studies have shown that in sepsis, moderate pyroptosis promotes the clearance of pathogens, whereas the excessive activation of pyroptosis leads to host immune response disorders and SAOD. Additionally, transcription factors, non-coding RNAs, epigenetic modifications and post-translational modifications can directly or indirectly regulate pyroptosis-related molecules. Pyroptosis also interacts with autophagy, apoptosis, NETosis, and necroptosis. This review summarizes the roles and regulatory mechanisms of pyroptosis in sepsis and SAOD. As our understanding of the functions of pyroptosis improves, the development of new diagnostic biomarkers and targeted therapies associated with pyroptosis to improve clinical outcomes appears promising in the future.

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Decoding LncRNAs

Cited by 20 publications

References 284 publications

The Role of lncRNA PCAT6 in Cancers

The Role of lncRNA PCAT6 in Cancers

Detection and analysis of long noncoding RNA expression profiles related to epithelial–mesenchymal transition in keloids

Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction

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