2024
DOI: 10.1186/s13287-024-03816-y
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Decoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing

Di Sun,
Xiaowen Zhang,
Rong Chen
et al.

Abstract: Background Dysfunction or deficiency of corneal epithelium results in vision impairment or blindness in severe cases. The rapid and effective regeneration of corneal epithelial cells relies on the limbal stem cells (LSCs). However, the molecular and functional responses of LSCs and their niche cells to injury remain elusive. Methods Single-cell RNA sequencing was performed on corneal tissues from normal mice and corneal epithelium defect models. Bi… Show more

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