Decoding antibacterial and antibiofilm properties of cinnamon and cardamom essential oils: a combined molecular docking and experimental study

Pourkhosravani, Elahe; Nayeri, Fatemeh Dehghan; Bazargani, Mitra Mohammadi

doi:10.1186/s13568-021-01305-6

Cited by 14 publications

(12 citation statements)

References 69 publications

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“…Furthermore, biofilm metabolic activity and quantification of biofilm biomass showed that Cinnamomum suppressed the E. coli metabolic activity and biofilm formation by 99% and 100%, respectively. Notably, gas chromatography-mass spectrometry (GC-MS) analysis revealed that E-cinnamaldehyde, α-terpinyl acetate, and copaene accounted for 91.31% of the Cinnamomum essential oil ( Pourkhosravani et al., 2021 ). Another investigation also reported that C. camphora essential oil (CCEO) killed clinical isolates of E. coli from dairy cows with clinical endometritis in both planktonic and biofilm communities.…”

Section: Inhibitory Effects Of Cinnamomum On Micro...mentioning

confidence: 99%

Cinnamomum: The New Therapeutic Agents for Inhibition of Bacterial and Fungal Biofilm-Associated Infection

Didehdar

Chegini

Tabaeian

et al. 2022

Front. Cell. Infect. Microbiol.

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Due to the potent antibacterial properties of Cinnamomum and its derivatives, particularly cinnamaldehyde, recent studies have used these compounds to inhibit the growth of the most prevalent bacterial and fungal biofilms. By inhibiting flagella protein synthesis and swarming motility, Cinnamomum could suppress bacterial attachment, colonization, and biofilm formation in an early stage. Furthermore, by downregulation of Cyclic di‐guanosine monophosphate (c‐di‐GMP), biofilm-related genes, and quorum sensing, this compound suppresses intercellular adherence and accumulation of bacterial cells in biofilm and inhibits important bacterial virulence factors. In addition, Cinnamomum could lead to preformed biofilm elimination by enhancing membrane permeability and the disruption of membrane integrity. Moreover, this substance suppresses the Candida species adherence to the oral epithelial cells, leading to the cell wall deformities, damage, and leakages of intracellular material that may contribute to the established Candida’s biofilm elimination. Therefore, by inhibiting biofilm maturation and destroying the external structure of biofilm, Cinnamomum could boost antibiotic treatment success in combination therapy. However, Cinnamomum has several disadvantages, such as poor solubility in aqueous solution, instability, and volatility; thus, the use of different drug-delivery systems may resolve these limitations and should be further considered in future investigations. Overall, Cinnamomum could be a promising agent for inhibiting microbial biofilm-associated infection and could be used as a catheter and other medical materials surface coatings to suppress biofilm formation. Nonetheless, further in vitro toxicology analysis and animal experiments are required to confirm the reported molecular antibiofilm effect of Cinnamomum and its derivative components against microbial biofilm.

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Section: Inhibitory Effects Of Cinnamomum On Micro...mentioning

confidence: 99%

Cinnamomum: The New Therapeutic Agents for Inhibition of Bacterial and Fungal Biofilm-Associated Infection

Didehdar

Chegini

Tabaeian

et al. 2022

Front. Cell. Infect. Microbiol.

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“…A study by Fabricant D. S. and Farnsworth N. R. in 2001 estimated that there were more than 250,000 species of higher plants on our planet, of which only 6% had been tested and evaluated for their biologic activity at the time [ 72 ]. Today, advanced screening techniques and assays have led to phytochemicals composing a significant part of the pharmaceutical market [ 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ]. Plants can be used as sources of medicinal active compounds using several methodologies.…”

Section: Phytochemicals As a Reservoir To Search For Sars-cov-2 Mpro ...mentioning

confidence: 99%

The Main Protease of SARS-CoV-2 as a Target for Phytochemicals against Coronavirus

Issa

Сокорнова

Zhidkin

et al. 2022

Plants

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In late December 2019, the first cases of COVID-19 emerged as an outbreak in Wuhan, China that later spread vastly around the world, evolving into a pandemic and one of the worst global health crises in modern history. The causative agent was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although several vaccines were authorized for emergency use, constantly emerging new viral mutants and limited treatment options for COVID-19 drastically highlighted the need for developing an efficient treatment for this disease. One of the most important viral components to target for this purpose is the main protease of the coronavirus (Mpro). This enzyme is an excellent target for a potential drug, as it is essential for viral replication and has no closely related homologues in humans, making its inhibitors unlikely to be toxic. Our review describes a variety of approaches that could be applied in search of potential inhibitors among plant-derived compounds, including virtual in silico screening (a data-driven approach), which could be structure-based or fragment-guided, the classical approach of high-throughput screening, and antiviral activity cell-based assays. We will focus on several classes of compounds reported to be potential inhibitors of Mpro, including phenols and polyphenols, alkaloids, and terpenoids.

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“…Many studies have shown that β-asarone and αasarone have good antifungal activities (SN Kumar, et al 2015, RK Joshi 2016 . Furthermore, it has been reported that the combined use of EOs can occasionally produce more signi cant antifungal effects (E Pourkhosravani, et al 2021, L Nißl, et al 2021 .…”

Section: Introductionmentioning

confidence: 99%

The antifungal effects of the essential oils of Artemisia argyi and Acorus tatarinowii on Panax notoginseng root rot disease

Ling

Liao

Nie

et al. 2022

Preprint

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Essential oils (EOs) have a potent antifungal effect. Traditional Chinese medicines Artemisia argyi and Acorus tatarinowii have significant research value. Gas chromatography–mass spectrometry (GC–MS) was used to examine the chemical components of EOs from two therapeutic products. Panax notoginseng root rot pathogenic fungi were employed as target strains. The effect of EOs on pathogenic fungi was confirmed using the Oxford cup method and the chessboard method. The findings revealed that the two EOs as well as their principal chemical components exhibited potent inhibitory effects on pathogenic P. notoginseng. The combination of A. argyi, A. tatarinowii and hymexazol improved the inhibition of Fusarium oxysporum and Fusarium solani. This finding demonstrates that EO has strong antifungal properties and has the potential to be widely manufactured and used in agriculture. Thus, it is hypothesized that understanding the antifungal activity of plant EOs, such as those from A. argyi and A. tatarinowii, will aid in the resolution of agricultural cultivation problems, such as crop diseases caused by P. notoginseng, and lay the groundwork for the future development of green pesticides.

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Decoding antibacterial and antibiofilm properties of cinnamon and cardamom essential oils: a combined molecular docking and experimental study

Cited by 14 publications

References 69 publications

Cinnamomum: The New Therapeutic Agents for Inhibition of Bacterial and Fungal Biofilm-Associated Infection

Cinnamomum: The New Therapeutic Agents for Inhibition of Bacterial and Fungal Biofilm-Associated Infection

The Main Protease of SARS-CoV-2 as a Target for Phytochemicals against Coronavirus

The antifungal effects of the essential oils of Artemisia argyi and Acorus tatarinowii on Panax notoginseng root rot disease

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