Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling

Jang, Sung Kyu; Kim, Seung Tae; Lee, Do Ik; Park, Jun Sub; Jo, Bo Ram; Park, Jung Youl; Heo, Jong; Joo, Seong Soo

doi:10.1155/2016/4541580

Cited by 7 publications

(4 citation statements)

References 28 publications

(26 reference statements)

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“…Telogen is the resting phase associated with inactivity of the hair follicle. The club hair is shed and new anagen hair growth begins, resuming the cycle [234].…”

Section: Introductionmentioning

confidence: 99%

Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study

Park

Lee

Shim³

et al. 2020

World J Mens Health

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PurposeProbiotic supplementation demonstrates beneficial effects on serum lipid profiles. We hypothesized that probiotics could benefit patients presenting with alopecia, secondary to improved blood flow to the scalp.Materials and MethodsOur study included men with stage II to V patterns of hair loss based on the Hamilton–Norwood classification and women with stage I to III patterns of hair loss based on the Ludwig classification. All patients were administered 80 mL of Mogut® (a kimchi and cheonggukjang probiotic product) twice a day. Hair growth and numbers were measured using the Triple Scope System® (KC Technology, Korea) at baseline and after 1 and 4 months of administration of a kimchi and cheonggukjang probiotic product.ResultsAt baseline, the mean hair count was 85.98±20.54 hairs/cm2 and the mean thickness was 0.062±0.011 mm in all patients (n=46). Hair count and thickness had significantly increased at 1 month (90.28±16.13 hairs/cm2 and 0.068±0.008 mm, respectively) and at 4 months (91.54±16.29 hairs/cm2 and 0.066±0.009 mm, respectively). In this study, we found that a kimchi and cheonggukjang probiotic product could promote hair growth and reverse hair loss without associated adverse effects such as diarrhea.ConclusionsWe suggest that the observed improvements in hair count and thickness resulted from initiation of the anagen phase in hair follicles in response to probiotics.

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“…Telogen is the resting phase associated with inactivity of the hair follicle. The club hair is shed and new anagen hair growth begins, resuming the cycle [234].…”

Section: Introductionmentioning

confidence: 99%

Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study

Park

Lee

Shim³

et al. 2020

World J Mens Health

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“…Targeting the β -catenin pathway is an ideal clinical therapy for preventing hair loss and enhancing hair regrowth. Therefore, many researchers have reported chemicals and natural extracts that stimulate hair growth by targeting the β -catenin pathway [13–15]. …”

Section: Introductionmentioning

confidence: 99%

The Hair Growth‐Promoting Effect of Rumex japonicus Houtt. Extract

Lee

Kim

Yang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increased β-catenin via the inhibition of GSK-3β. In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and β-catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth.

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“…Hair plays an important role in the stability of skin tissue, including preventing ultraviolet radiation, regulating body temperature, and releasing secretions [ 1 ]. Hair has the capacity to regenerate by the appendage of the skin-hair follicle, in order to retain these functions [ 2 – 4 ]. At present, drugs for treating alopecia mainly play a role by reducing hair follicle loss or promoting hair growth, but hair transplantation only transfers hair follicles from healthy parts to damaged parts, which cannot solve the root of the problem.…”

Section: Introductionmentioning

confidence: 99%

Th22 is the effector cell of thymosin β15-induced hair regeneration in mice

Tao,

Ying,

et al. 2024

Inflamm Regener

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Background Thymosin beta family has a significant role in promoting hair regeneration, but which type of T cells play a key role in this process has not been deeply studied. This research aimed to find out the subtypes of T cell that play key role in hair regeneration mediated by thymosin beta 15 (Tβ15). Methods Ready-to-use adenovirus expressing mouse Tmsb15b (thymosin beta 15 overexpression, Tβ15 OX) and lentivirus-Tβ15 short hairpin RNA (Tβ15 sh) were used to evaluate the role of Tβ15 in hair regeneration and development. The effect of Th22 cells on hair regeneration was further studied by optimized Th22-skewing condition medium and IL-22 binding protein (IL-22BP, an endogenous antagonist of IL-22, also known as IL-22RA2) in both ex vivo culture C57BL/6J mouse skin and BALB/c nude mice transplanted with thymus organoid model. Results The results show that Tβ15, the homologous of Tβ4, can promote hair regeneration by increasing the proliferation activity of hair follicle cells. In addition, high-level expression of Tβ15 can not only increase the number of Th22 cells around hair follicles but also accelerate the transformation of hair follicles to maturity. Consistent with the expected results, when the IL-22BP inhibitor was used to interfere with Th22, the process of hair regeneration was blocked. Conclusions In conclusion, Th22 is the key effector cell of Tβ15 inducing hair regeneration. Both Tβ15 and Th22 may be the potential drug targets for hair regeneration.

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Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling

Cited by 7 publications

References 28 publications

Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study

Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study

The Hair Growth‐Promoting Effect of Rumex japonicus Houtt. Extract

Th22 is the effector cell of thymosin β15-induced hair regeneration in mice

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