Declínio da prevalência do HTLV-1/2 em doadores de sangue do Hemocentro Regional da Cidade de Uberaba, Estado de Minas Gerais, 1995 a 2008

Lima, Guilherme Manso de; Eustáquio, José Martins Juliano; Martins, Raquel A.; Josahkian, Juliana Alves; Pereira, Gilberto de Araújo; Moraes‐Souza, Helio; Martins, Paulo Roberto Juliano

doi:10.1590/s0037-86822010000400017

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…No positivity occurred in the current study and it should be emphasized that infection by the virus is in sharp decline according to studies of blood donors in Uberaba, Minas Gerais which assessed the prevalence of HTLV-I and II between 1995 and 2008. The prevalence for 1995-2000 was 0.6%, whereas it declined to 0.1% during the 2002-2008 period (27) .…”

Section: Discussionmentioning

confidence: 99%

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Borelli¹,

Mazzola²,

Matta³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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BackgroundSo that an improvement in the selection of donors can be achieved and the risk to the recipient of transfused blood can be reduced, prospective donors are submitted to clinical and serological screening. ObjectiveThis study investigated the blood discard rate and the rate of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil. MethodsThis study was an exploratory cross-sectional descriptive investigation with a quantitative approach of donations between January and December 2011. ResultsIn the study period the Regional Blood center in Maringá, Brazil received 8337 blood donations from people living in the city and neighboring towns. However, 278 (3.33%) donations were discarded during serological screening owing to one or more positive serological markers. A total of 46.4% of the discarded blood units were confirmed positive by serology with anti-HBc being the most common (66.7%), followed by syphilis (22.5%), HBsAg (4.7%), anti-hepatitis C virus (3.1%), human immunodeficiency virus (1.5%) and Chagas' disease (1.5%). The rate of infectious-contagious diseases that can be transmitted by blood transfusions was 1.55% (129/8337) of the donor population with a frequency of 1.03% for anti-HBc and 0.35% for syphilis. ConclusionThis study demonstrates a high prevalence of the anti-HBc marker in prospective blood donors from provincial towns in the state of Paraná, Brazil.

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Section: Discussionmentioning

confidence: 99%

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Borelli¹,

Mazzola²,

Matta³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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“…Later on, blood bank screening was applied in developing countries with medium to high seroprevalence among blood donors (Argentina: 2004, Peru: 1999). This policy proved to be successful to decrease HTLV-1 spread by blood transfusion [300–304]. Unfortunately, official screening programs still lack in other regions with high prevalence (Middle East) [305,306], further reflecting differences between industrialized and developing countries.…”

Section: Blv As a Model For Htlv Therapy And Preventionmentioning

confidence: 99%

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Rodríguez

Florins

Gillet

et al. 2011

Viruses

172

126

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Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.

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“…Any inference about a possible increase in the prevalence of HTLV-1/2 in Manaus is limited by the rarity of the event and the relative small sample size of the 1997 study. However, it is reasonable to assume that the prevalence of HTLV-1/2 in Manaus has not decreased as has been observed in other locations, including Brazil and Japan 8,14,15 . The decreased HTLV-1/2 observation rate is likely due to increased specifi city of diagnostic tests, which has led to the reduction in the proportion of false positives, or a real reduction in the transmission rate of the disease in populations with better access to education and prevention initiatives administered by the public health services.…”

mentioning

confidence: 93%

Absence of HTLV-1/2 infection and dermatological diseases in Manaus, State of Amazonas, Brazil

Passos

Moraes

Tamegão-Lopes

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction:The prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection is heterogeneous across different populations. We tested the hypothesis that HTLV-1/2 infection occurs more often in dermatological patients. Methods: A total of 1,091 patients from a tropical dermatology clinic were tested for HTLV-1/2. In parallel, 6865 fi rst-time blood donors from the same geographic area were screened for HTLV-1/2; HTLV-1/2 positive blood donors underwent dermatological examinations. Results: The prevalence of HTLV-1/2 in fi rst-time blood donors was 0.14%. No co-occurrence of HTLV-1/2 infection and dermatological conditions was observed. Conclusions: Our results challenge the hypothesis that HTLV-1/2 infection occurs more often in dermatological patients.Keywords: HTLV-1/2. Dermatology. Association. HTLV and skin diseases.Human T-cell lymphotropic virus (HTLV) was fi rst identifi ed in 1980. It is a member of the Retroviridae family, sub-family Ortothoretroviridae 1 . The global distribution of HTLV is heterogeneous, with high prevalence in Japan, the Caribbean, and South and Central America, and low prevalence in the Middle East and Melanesia 2 . Prevalence studies, performed in blood donors, indigenous populations, and pregnant women in Brazil, suggest that there are an estimated 2 million carriers of HTLV-1/2, and that the distribution varies based on ethnicity, race, and/or population groups 3 . In 1997, a positive test rate for HTLV-1/2 of 0.08% was observed in 2 independent population samples of 1,200 blood donors from Manaus and Florianópolis, and a positive test rate of 1.35% was observed in 1,040 blood donors from Salvador 4 . In a survey of more than 6 million blood donors from 27 Brazilian urban centers, the prevalence of HTLV-1/2 ranged from 0.04% in Florianópolis to 1% in São Luis, with a national average of 0.326% 5. In Manaus, the positive test rate reached 0.53%, which was much higher than was reported in 1997; however, the 2005 study did not confi rm positive enzyme-linked immunosorbent assay (ELISA) test results by Western Blot. In 2003, a study of 11,121 blood donor samples from the State of Acre reported that 12 (0.11%) samples were positive for HTLV: 8 (0.07%) samples were positive for HTLV-1, 2 (0.02%) samples were positive for HTLV-2, and 2 (0.02%) samples were indeterminate6 .An estimated 95% of individuals infected by HTLV remain asymptomatic; however, 2% develop adult T-cell lymphoma/ leukemia (ATLL) and 2-3% present with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) 7,8 . In addition, uveitis 9 is associated with HTLV-I. Dermatoses, including infective dermatitis 10 , neoplasia, Norwegian scabies, acquired ichthyosis, and dermatophytosis 11 are associated with HTLV-I infection. These associations suggest that HTVL-I/II may be more prevalent in individuals presenting skin diseases. Interestingly, in the Brazilian State of Minas Gerais, 0.7% of 1,229 patients at a dermatology clinic tested positive for HTLV-1/2, which is 3.3 times higher ...

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Declínio da prevalência do HTLV-1/2 em doadores de sangue do Hemocentro Regional da Cidade de Uberaba, Estado de Minas Gerais, 1995 a 2008

Cited by 8 publications

References 19 publications

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Absence of HTLV-1/2 infection and dermatological diseases in Manaus, State of Amazonas, Brazil

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