Declining testicular function with age

Stearns, Eric L.; MacDonnell, Johanna; Kaufman, Benjamin; Padua, Raymond R.; Lucman, T.S.; Winter, Jeremy S.D.; Faiman, Charles

doi:10.1016/0002-9343(74)90850-x

Cited by 252 publications

(40 citation statements)

References 21 publications

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“…We reported that serum T levels remained within the same range from adolescence to the age of the 7th decade, then from the 8th decade its levels rapidly decreased. This corresponds very well the observation of Coppage and Cooner (1975), Kent and Acone (1966), Frick and Kinol (1969) and Stearns et al (1974). In contrast to T the change of serum DHT with age has not been established.…”

supporting

confidence: 89%

“…The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka-shi 812, Japan Various reports on the influences of aging on plasma T levels have been made Coppage and Cooner (1965), Kent and Acone (1966), Frick and Kinol (1969) and Stearns et al (1974) reported that male plasma T levels remained within the same range from adolescence till old age. However, Kirschner et al (1968) and Vermeulen et al (1972) reported lower plasma T levels in old males.…”

mentioning

confidence: 99%

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Age-dependent change of serum 5.ALPHA.-dihydrotestosterone and its relation to testosterone in man.

1977

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supporting

confidence: 89%

mentioning

confidence: 99%

Age-dependent change of serum 5.ALPHA.-dihydrotestosterone and its relation to testosterone in man.

1977

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“…Adolescence was chosen because this is the period when the incidence of testis cancer starts to rise sharply and testicular activity, as indicated by the blood levels of testosterone, is rising most quickly, reaching a peak around age 20 (Vermeulen et al, 1971;Stearns et al, 1974 As it is obviously difficult for adults to remember their food consumption in adolescence, thereby introducing scope for recall bias, subjects were asked:…”

Section: Methodsmentioning

confidence: 99%

Adolescent milk, dairy product and fruit consumption and testicular cancer

Davies

Palmer²,

Ruja³

et al. 1996

Br J Cancer

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Summary There is an association between dairy product consumption and the incidence of testicular cancer in different countries. To test the hypothesis that milk and dairy products are risk factors, a case-control study was performed in East Anglia, UK. All the cases were men with testicular cancer and for each of the 200 cases there were four controls, two cancer controls and two population controls. The response rate of those eligible subjects who received a questionnaire was: cases 73%, cancer controls 65% and population controls 57%. All responding subjects completed a dietary questionnaire including questions on current and adolescent milk, dairy product and fruit and vegetable consumption. The answers were corroborated when possible by the subjects' mothers using a separate questionnaire. MethodsThe hypothesis was tested by a case -control study. Adolescence was chosen because this is the period when the incidence of testis cancer starts to rise sharply and testicular activity, as indicated by the blood levels of testosterone, is rising most quickly, reaching a peak around age 20 (Vermeulen et al., 1971;Stearns et al., 1974 As it is obviously difficult for adults to remember their food consumption in adolescence, thereby introducing scope for recall bias, subjects were asked:(1) about current consumption, which they then used as a reference for consumption in adolescence; (2) to send a questionnaire to their mothers (if possible).

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“…Several studies have demonstrated diminished Leydig cell function secondary to aging with small declines in serum testosterone levels beginning after the 6th decade [12][13][14], Serum LH and FSH levels have been shown to only increase slightly between the 4th and 7th decade with more pronounced increases noted after the age of 70 years [13,14]. It seems unlikely, however, that superimposed gonadal dysfunction related to senescence played a signifi cant role in our series with a mean age of 51 years, the eldest subject being only 62 years.…”

Section: Discussionmentioning

confidence: 99%

Effects of Long-Term Testosterone Administration on Pituitary-Testicular Axis in End-Stage Renal Failure

Barton

Mirahmadi

Vaziri³

1982

Nephron

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The endocrine effects of long-term testosterone administration were studied in 6 end-stage renal failure patients. During a 3-month control period where no androgens were administered the mean plasma testosterone level (7.3 nmol/l) was depressed while mean plasma follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) levels were elevated at 41.2 mU/ml, 105.5 mU/ml, and 63 ng/ml, respectively. These values were repeated during a 6-month study period where each subject was administered testosterone enanthate (400 mg) intramuscularly once a week. Plasma testosterone levels markedly increased in all subjects with a mean elevation of 72.4 nmol/l, while reductions were observed in FSH and LH levels with values of 2.7 and 16.3 mU/ml, respectively. When compared with control period values, these changes were statistically significant (p < 0.05). Although the mean plasma PRL level of 49.0 ng/ml was reduced when compared with the control period values, this reduction was not statistically significant. Our control period findings of low plasma testosterone levels coupled with high plasma LH and FSH are consistent with Leydig cell dysfunction. The significant reductions in plasma FSH and LH noted during the study period indicate a negative feedback effect produced by the pharmacologic doses of testosterone. Long-term testosterone administration, however, did not significantly affect the elevated mean PRL levels observed in these subjects.

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Declining testicular function with age

Cited by 252 publications

References 21 publications

Age-dependent change of serum 5.ALPHA.-dihydrotestosterone and its relation to testosterone in man.

Age-dependent change of serum 5.ALPHA.-dihydrotestosterone and its relation to testosterone in man.

Adolescent milk, dairy product and fruit consumption and testicular cancer

Effects of Long-Term Testosterone Administration on Pituitary-Testicular Axis in End-Stage Renal Failure

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