Declining prevalence and increasing awareness of hepatitis C virus infection in Italy: a population-based survey

Andriulli, Angelo; Stroffolini, T.; Valvano, Maria Rosa; Grattagliano, Ignazio; Ippolito, Alessio; Grossi, A.; Brancaccio, Giuseppina; Coco, C.; Russello, Maurizio; Smedile, Antonina; Petrini, Elisa; Martini, Silvia; Gaeta, G.B.; Rizzetto, M.

doi:10.1016/s0168-8278(17)30849-8

Cited by 9 publications

(22 citation statements)

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“…This is the case in Italy where a recent epidemiological study in Sicily found that about 70% of infections were observed in subjects >60 years old and 30% in those >75 years old (Rete HCV Sicilia, unpublished data). Similar results were observed in another independent Italian epidemiological study which found that 50% of infected subjects were >70 years old …”

Section: Epidemiology Of Hcv Infection: More Than 70 Million Persons supporting

confidence: 90%

“…Similar results were observed in another independent Italian epidemiological study which found that 50% of infected subjects were >70 years old. 16 Thus, HCV infection is highly prevalent worldwide with differences in age groups and countries, and strategies to eliminate HCV should take into account the epidemiological data as well as the cost of treatment and financial situation in different countries.…”

Section: Epidemiology Of Hcv Infection: More Than 70 Million Personmentioning

confidence: 99%

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Is global elimination of HCV realistic?

Calvaruso

Petta

2018

Liver International

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The elimination of hepatitis C virus (HCV) has been made possible through the availability of new antiviral drugs which may now be administered to all patients with HCV infection, even those with decompensated cirrhosis. The goal of the World Health Organization (WHO) is to reduce the incidence of chronic hepatitis infection from the current 6-10 million to 0.9 million cases of chronic infections by 2030, and annual deaths from 1.4 million to fewer than 0.5 million. Achieving these targets will require

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Section: Epidemiology Of Hcv Infection: More Than 70 Million Persons supporting

confidence: 90%

Section: Epidemiology Of Hcv Infection: More Than 70 Million Personmentioning

confidence: 99%

Is global elimination of HCV realistic?

Calvaruso

Petta

2018

Liver International

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“…The highest prevalence rates have been reported in Southern Italy, though many of these earlier studies were conducted in smaller, more rural areas. Recent studies have also reported decreasing rates of HCV prevalence in the country …”

Section: Discussionmentioning

confidence: 96%

“…A true cascade of care for HCV infection is lacking in Italy as the number of patients under care remains uncertain. Recent studies reported between 20% and 80% of HCV+ individuals are aware of their status . This uncertainty has clear implications for treatment, as the population first needs to be identified in order to be placed in care.…”

Section: Discussionmentioning

confidence: 99%

“…First, a Markov HCV disease progression model (the “Italy Polaris model”) was built using previously described methodology to forecast the annual prevalence of chronic HCV infection in Italy by liver disease stage, sex and age. In this model, the number of annual historical HCV incident cases, starting in 1950, and their sex and age group distribution was back‐calculated to match the modelled prevalence by sex and age group in 2015 to reported estimates (Section 1 in Appendix ). The reported number of annual treated patients as tracked in the AIFA Monitoring Registry for DAAs was allocated to the age and liver disease stage of the eligible HCV‐infected population by the relative size of population in each treatment‐eligible disease stage (Table ).…”

Section: Methodsmentioning

confidence: 99%

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Forecasting Hepatitis C liver disease burden on real‐life data. Does the hidden iceberg matter to reach the elimination goals?

Kondili

Scott

Blach

et al. 2018

Liver International

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Background & AimsAdvances in direct‐acting antiviral treatment of HCV have reinvigorated public health initiatives aimed at identifying affected individuals. We evaluated the possible impact of only diagnosed and linked‐to‐care individuals on overall HCV burden estimates and identified a possible strategy to achieve the WHO targets by 2030.MethodsUsing a modelling approach grounded in Italian real‐life data of diagnosed and treated patients, different linkage‐to‐care scenarios were built to evaluate potential strategies in achieving the HCV elimination goals.ResultsUnder the 40% linked‐to‐care scenario, viraemic burden would decline (60%); however, eligible patients to treat will be depleted by 2025. Increased case finding through a targeted screening strategy in 1948‐1978 birth cohorts could supplement the pool of diagnosed patients by finding 75% of F0‐F3 cases. Under the 60% linked‐to‐care scenario, viraemic infections would decline by 70% by 2030 but the patients eligible for treatment will run out by 2028. If treatment is to be maintained, a screening strategy focusing on 1958‐1978 birth cohorts could capture 55% of F0‐F3 individuals. Under the 80% linked‐to‐care scenario, screening limited in 1968‐1978 birth cohorts could sustain treatment at levels required to achieve the HCV elimination goals.ConclusionIn Italy, which is an HCV endemic country, the eligible pool of patients to treat will run out between 2025 and 2028. To maintain the treatment rate and achieve the HCV elimination goals, increased case finding in targeted, high prevalence groups is required.

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