Declining Incidence of Hepatocellular Carcinoma in Osaka, Japan, from 1990 to 2003

Tanaka, Hideo; Imai, Yumiko; Hiramatsu, Naoki; Ito, Yuri; Imanaka, Kazuho; Oshita, Masahide; Hijioka, Taizo; Katayama, Kazuhiro; Yabuuchi, Iwao; Yoshihara, Hiroyuki; Inoue, Akira; Kato, Masaaki; Takehara, Tetsuo; Tamura, Shinji; Kasahara, Akinori; Hayashi, Norio; Tsukuma, Hideaki

doi:10.7326/0003-4819-148-11-200806030-00004

Cited by 112 publications

(108 citation statements)

References 16 publications

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“…In Japan, HCV is the main risk factor for HCC (25) and significant declines in liver cancer incidence rates in this country have been attributed to reduced transmission of HCV since the 1950s and 1960s as a result of the change in blood bank donation policies from a paid to voluntary system as well as to more stringent legal penalties deterring parenteral amphetamine use, which had increased after the devastation to the country in World War II (10). Historically, the primary risk factors for liver cancer in China and the Philippines have been HBV infection and dietary aflatoxin exposure (China only), and these 2 factors have been shown to have a synergistic effect on HCC (16).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies from a variety of international sources have reported trends in liver cancer incidence rates, including increasing trends in developed countries with historically low liver cancer incidence rates and decreasing trends in areas with the highest observed liver cancer incidence in the world (7)(8)(9)(10)(11). However, these studies were limited because they were country-or region-specific (8)(9)(10)(11) or because they were based on old data sets (7).…”

Section: Introductionmentioning

confidence: 95%

“…However, these studies were limited because they were country-or region-specific (8)(9)(10)(11) or because they were based on old data sets (7). In this article, we present the contemporary variation in liver cancer incidence patterns across 5 continents by examining incidence rates provided by the International Agency for Research on Cancer (IARC) for 32 select cancer registries around the globe over a 10-year time period (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002).…”

Section: Introductionmentioning

confidence: 99%

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International Trends in Liver Cancer Incidence Rates

Center

Jemal

2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

248

184

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Background: Several previous studies have documented region or country-specific liver cancer incidence trends around the world. However, no study has systematically examined the international pattern using the most recently updated incidence data from the International Agency for Research on Cancer.Methods: We examined recent trends in liver cancer incidence rates from 1993 to 2002 by joinpoint analysis for 32 cancer registries worldwide, using Cancer Incidence in Five Continents. We also examined the male to female rate ratios for these and four additional registries, based on the 1998-2002 incidence data.Results: Liver cancer incidence rates for both men and women statistically significantly increased from 1993 to 2002 for 8 of 32 cancer registries considered in the analysis. Increases were largely confined to economically developed countries of Western Europe, North America, and Oceania. In contrast, rates decreased in both men and women in 5 registries including 3 in Asia. Despite this, the incidence rates in Asian countries are twice as high as those in Africa and more than four times as high as rates in North America. Male to female rate ratios varied from 0.9 in sub-Saharan African and South American registries to 5.0 in France and Egypt.Conclusions: Liver cancer incidence rates continue to increase in some low-risk parts of the world whereas they are decreasing in some of the highest risk countries in Asia. Etiologic studies are required to further elucidate factors contributing to the divergent liver cancer incidence trends worldwide.Impact: Our description of international liver cancer incidence trends may stimulate further etiologic studies. Cancer Epidemiol Biomarkers Prev; 20(11); 2362-8. Ó2011 AACR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

International Trends in Liver Cancer Incidence Rates

Center

Jemal

2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

248

184

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“…However, these data need to be interpreted carefully and it appears to be unlikely that HCV is a key determinant in the development if IBM. The increasing incidence of IBM in Japan is in strong contrast to the decreasing incidence in HCV infections 66, 67, 68. Moreover, countries with relatively high incidence rates of HCV infections belong to the regions that are stricken the least by IBM 26, 30, 61, 69, 70, 71.…”

Section: Pathomechanisms In Ibmmentioning

confidence: 98%

Immune and myodegenerative pathomechanisms in inclusion body myositis

Keller

Schmidt

Lünemann

2017

Ann Clin Transl Neurol

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Inclusion Body Myositis (IBM) is a relatively common acquired inflammatory myopathy in patients above 50 years of age. Pathological hallmarks of IBM are intramyofiber protein inclusions and endomysial inflammation, indicating that both myodegenerative and inflammatory mechanisms contribute to its pathogenesis. Impaired protein degradation by the autophagic machinery, which regulates innate and adaptive immune responses, in skeletal muscle fibers has recently been identified as a potential key pathomechanism in IBM. Immunotherapies, which are successfully used for treating other inflammatory myopathies lack efficacy in IBM and so far no effective treatment is available. Thus, a better understanding of the mechanistic pathways underlying progressive muscle weakness and atrophy in IBM is crucial in identifying novel promising targets for therapeutic intervention. Here, we discuss recent insights into the pathomechanistic network of mutually dependent inflammatory and degenerative events during IBM.

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“…The liver cancer mortality in young people in Qidong demonstrates a continuously falling trend . The incidence of HCC in Osaka started to decrease by 2000, mainly because of decreased HCV-related HCC (Tanaka et al, 2008).…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%