Declining energy predicts incident mobility disability and mortality risk in healthy older adults

Abstract

after first online publication: In the "Results" section of the Abstract, "35% risk of death" has been changed to "33% risk of death".]

Vitality Revisited: The Evolving Concept of Flourishing and Its Relevance to Personal and Public Health

“…Vitality is a unidimensional construct that considers both negative and positive states; that is, the presence of energy (energy as a positive asset) and the absence of fatigue (fatigue as a negative indicator/hinderance to vitality) [ 14 ]. Vitality also links integrated biopsychosocial theories of human functioning along a health continuum [ 109 , 110 , 111 , 112 ]. The research shows that vitality is positively associated with an individual’s quantity and quality of social contacts [ 113 ], and while vitality appears to be a factor in the promotion/maintenance of healthy lifestyle behaviors, intervention studies suggest that vitality is also a product of healthy dietary practices and regular physical activity [ 114 , 115 ].…”

Editorial: Feelings of energy and fatigue: Two different moods

“…However, Loy et al ( 2018 ) provided evidence that biologically energy and fatigue may indeed be two distinct unipolar moods. Since then, multiple studies have provided evidence that energy and fatigue may have both distinct and overlapping biological (Loy and O'Connor, 2016 ; Eshragh et al, 2017 ; Boolani et al, 2019a , 2022a ; Dupree et al, 2019 ), behavioral (Boolani and Manierre, 2019 ; Boolani et al, 2019a ; Papadakis et al, 2022 ), and biomechanical correlates (Boolani et al, 2020 , 2022a ; Kowalski et al, 2021 ; Mahoney et al, 2021 ; Sprague et al, 2021 ; Kadry et al, 2022 ). The strength of this evidence is mixed with several studies providing evidence from randomized controlled crossover designs (Loy and O'Connor, 2016 ; Dupree et al, 2019 ; Boolani et al, 2020 ), while others relied on cross-sectional designs (Eshragh et al, 2017 ; Boolani and Manierre, 2019 ; Boolani et al, 2019b , 2022b ; Kowalski et al, 2021 ; Mahoney et al, 2021 ; Kadry et al, 2022 ; Papadakis et al, 2022 ) and two studies examined longitudinal data (Sprague et al, 2021 ; Boolani et al, 2022c ), while another was a review of literature (Loy et al, 2018 ).…”

“…The case for measuring both energy and fatigue is most effectively illustrated by Sprague et al ( 2021 ) and Zhang et al , who provided evidence that declines in feelings of energy and increase in feelings of fatigue increase risk of mortality. Sprague et al ( 2021 ) provided evidence that declines in feelings of energy significantly increased risks for mortality and decreased functional capacity, while changes in feelings of fatigue did not.…”

“…The case for measuring both energy and fatigue is most effectively illustrated by Sprague et al ( 2021 ) and Zhang et al , who provided evidence that declines in feelings of energy and increase in feelings of fatigue increase risk of mortality. Sprague et al ( 2021 ) provided evidence that declines in feelings of energy significantly increased risks for mortality and decreased functional capacity, while changes in feelings of fatigue did not. Conversely Zhang et al report that a combination of frailty, a measure consisting of fatigue, and neutrophil-to-lymphocyte ratio (NLR), a marker of fatigue (Loy et al, 2018 ), had the greatest impact on mortality in patients with a diagnosis of cancer ( Zhang et al ).…”

“…Conversely Zhang et al report that a combination of frailty, a measure consisting of fatigue, and neutrophil-to-lymphocyte ratio (NLR), a marker of fatigue (Loy et al, 2018 ), had the greatest impact on mortality in patients with a diagnosis of cancer ( Zhang et al ). These studies ( Zhang et al ; Sprague et al, 2021 ) provide conflicting information in terms of the role that energy and fatigue play in mortality. However, these opposing findings may be explained by the fact that Sprague et al ( 2021 ) measured energy and fatigue as two distinct constructs, in what started as a healthy population, whereas Zhang et al addressed a population of cancer patients.…”