Declining Cholecystectomy Rate During the Era of Statin Use in Finland: A Population-Based Cohort Study Between 1995 and 2009

Abstract

Background and Aims: Aging with comorbidities, obesity, and rapid recovery from operation may increase the need for laparoscopic cholecystectomy, but long-term use of statins may be associated with a decreased risk of gallstones. This population-based cohort study presents the changing rate and causative factors of laparoscopic cholecystectomy in Finland during the era of statin use.

Statin Use and Reduced Risk of Biliary Tract Cancers in the United Kingdom Clinical Practice Research Datalink

“…Our findings are in line with the one previous study focusing on one individual type of BTC (cholangiocarcinoma) in Taiwan, which reported that the adjusted OR for statin use versus nonuse for cholangiocarcinoma was 0.80 (95%CI: 0.71-0.90). [27] The results are also consistent with studies that have demonstrated a decreased risk of gallstone disease, [12,13,14,15] a risk factor for BTCs, [28] especially GBC. [1,2] Statins could potentially reduce risk of BTCs through suppression of biliary cholesterol secretion and saturation and anti-inflammatory and endothelial effects.…”

“…Statins are commonly used cholesterol-lowering medications that have demonstrated effectiveness in the primary and secondary prevention of cardiovascular disease. [11] Several studies have shown that statins are associated with a lower risk of gallstone disease (gallstones or a history of cholecystectomy) [12,13,14,15], but associations with BTCs have not been well studied. To further our understanding of the associations between statins and BTCs, we thus conducted a nested case-control study within a large database of primary care electronic medical records -the United Kingdom (UK) Clinical Practice Research Datalink (CPRD).…”

Geographical differences in upper abdominal resectional surgery and high-volume procedures in Sweden during 2009–2011

“…From a population perspective, however, resectional surgery represents a small part of upper abdominal surgery in absolute numbers. Cholecystectomy was the most common procedure in the present study, 173/100 000 inhabitants, and similar operation rates have been reported [15][16][17]. Surgical traditions, and local indications for surgical or conservative treatment of primary cholecystitis, influence the number of cholecystectomies per capita, as well as simultaneous cholecystectomies performed in liver and pancreatic resections.…”

Bleeding complications in cholecystectomy: a register study of over 22 000 cholecystectomies in Finland

“…In the analysis of 10 174 LCs by Z’graggen and co-workers [ 9 ], bleeding was also the most frequent intraoperative complication occurring in 1,97 % of the cases. In a Finnish series of 1581 LCs, incidence of all bleeding complications was 1.1 % [ 22 ] and bleeding complications requiring reoperation occurred in 0.5 % of the cases [ 23 ]. Roslyn and co-workers [ 4 ] reported the overall incidence of bleeding complications of 0.4 % in the analysis of 42 474 OCs.…”