Declining bone marrow harvest quality over 24 years: a single institution experience

Spitzer, Thomas R.; Kim, Se Eun; Cohen, Rachel; Mathews, Richard D.; Li, Shuli; McAfee, Steven L.; Dey, Bimalangshu R.; El‐Jawahri, Areej; DeFilipp, Zachariah; Frigault, Matthew J.; O’Donnell, Paul V.; Hunnewell, Chrisa; Saylor, Meredith; Vanderklish, Julie; Danielson, Colleen; Poliquin, Cathleen; Chen, Yi Bin

doi:10.1038/s41409-020-01143-3

Cited by 5 publications

(1 citation statement)

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“…Moreover, as less BM collections take place, hospitals find it more difficult to maintain competent harvesting teams, making it harder to obtain adequate BM products. A recent study found that while BM volumes collected increased with time, cell concentrations decreased, putting both donors and patients at risk of adverse outcomes [6]. As higher nucleated cell doses are associated with less transplant-related mortality and improved survival after related and unrelated donor HCT, the difficulty in obtaining high-quality BM products could in turn skewer the balance even more towards PB harvests.…”

Section: Introduction and Objectivesmentioning

confidence: 99%

Use of plerixafor to mobilize haematopoietic progenitor cells in healthy donors

et al. 2021

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Increased transplant activity calls for improved stem cell collection, especially when peripheral blood is the preferred source of haematopoietic progenitor cells (HPCs).Plerixafor is a bicyclam molecule that mobilizes CD34+ cells by reversibly disrupting CXCR4-CXCL12-supported HPC retention. Plerixafor is given with granulocyte colony-stimulating factor (G-CSF) to help harvest autologous CD34+ cells for transplantation when mobilization with G-CSF fails. Mobilization protocols with the same doses of plerixafor and G-CSF have been used off-label in healthy allogeneic donors, with equal success and scarce side effects, both in adult and paediatric patients.Plerixafor has also been used as a sole mobilization agent. Plerixafor alone or coupled with G-CSF might lead to harvesting distinct cellular populations conferring improved engraftment properties and increased survival. Those characteristics might make plerixafor an especially attractive mobilization agent, particularly for non-related donations. However, available data are limited, and long-term follow-up is needed to clarify the best scenario for using plerixafor with or without G-CSF in healthy donors.In this review, we will summarize the evidence supporting this practice, highlighting the practical aspects and providing clues for an expanded use of plerixafor.

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Section: Introduction and Objectivesmentioning

confidence: 99%