Abstract:Background
Kidney transplant recipients (KTRs) commonly suffer from impaired immunity. KTRs’ compromised immune response to COVID-19 vaccines indicates urgent revision of immunisation policies.
Methods
A cross-sectional study was conducted in Madinah, Saudi Arabia of 84 KTRs who had received at least one dose of a COVID-19 vaccine. ELISA was used to evaluate anti-spike SARS-CoV-2 IgG and IgM antibody levels in blood samples obtained one month and seven months after vacc… Show more
“…( Phattraprayoon et al, 2022 ). Additionally, kidney transplant recipients who were vaccinated with COVID-19 vaccines showed a significant and dramatic decline of antibody levels over time ( Mahallawi et al, 2023 ).…”
“…( Phattraprayoon et al, 2022 ). Additionally, kidney transplant recipients who were vaccinated with COVID-19 vaccines showed a significant and dramatic decline of antibody levels over time ( Mahallawi et al, 2023 ).…”
“…Interestingly, a recent study demonstrated that viral-vector, and heterogenous of all homogenous mRNA-COVID-19 vaccines revealed reduction of levels of anti-S1 IgG between the first and third serum samples [18]. No differences between serum anti-S1 IgG levels at one and six-months after mRNA-COVID-19 vaccination in KTRs with one-month-post-mRNA-COVID-19vaccination-IgG-immune-response seropositivity and different factors through linear regression analysis [18]. Among the immunocompromised population, including KTRs, DPs, PDs, at least three doses of mRNA-COVID-19 vaccination was recommended to be the preparation of choice [20,22].…”
A comprehensive search was carried out in mainstream bibliographic databases or Medical Subject Headings, including ScienDirect, PubMed, Scopus, and ISI Web of Science, following the PRISMA 2020 Guideline. The search was applied to the articles that were published between 2021 and mid-2023. With strict literature search and screening processes, it yielded 7 articles from 349 articles of initial literature database. A number of previous studies demonstrated that KTRs or non-KTRs with renal failure markedly reduced vaccine response, whereas adaptive protocols of mRNA COVID-19 vaccination or alternative adjuvant vaccines is now not known yet. A recent study revealed that acute kidney injury and mortality could be caused by SARS-CoV-2 (COVID-19) around 50 % and 23 % of the infected KTRs. In conclusion, among the immunocompromised population, including KTRs, DPs, PDs, at least three doses of mRNA-COVID-19 vaccination was recommended to be the preparation of choice. Withdrawal of the immunosuppressants in KTRs and immunocompromised individual’s prior COVID-19 vaccination and at least third dose of mRNA-COVID-19 vaccination should be performed.
A comprehensive search was carried out in mainstream bibliographic databases or Medical Subject Headings, including ScienDirect, PubMed, Scopus, and ISI Web of Science. The search was applied to the articles that were published between 2021 and mid-2023. With strict literature search and screening processes, it yielded 8 articles from 349 articles of initial literature database. A number of previous studies demonstrated that KTRs or non-KTRs with renal failure markedly reduced vaccine response, whereas adaptive protocols of mRNA COVID-19 vaccination or alternative adjuvant vaccines is now not known yet. A recent study revealed that acute kidney injury and mortality could be caused by SARS-CoV-2 (COVID-19) around 50 % and 23 % of the infected KTRs. No different post-V4-T-cell response and anti-S antibody levels were detected by vaccine type combination (ChAdOx1 plus BNT162b2) among participants, whereas post-V3 seropositivity demonstrated more anti-S antibody levels if administered with BNT162b2, in comparison with ChAdOx1. In conclusion, among the immunocompromised population, including KTRs, DPs, PDs, at least three doses of mRNA-COVID-19 vaccination was recommended to be the preparation of choice. Withdrawal of the immunosuppressants in KTRs and immunocompromised individual’s prior COVID-19 vaccination and at least third dose of mRNA-COVID-19 vaccination should be performed.
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