Decline in Semicircular Canal and Otolith Function With Age

Agrawal, Yuri; Zúñiga, M. Geraldine; Davalos-Bichara, Marcela; Schubert, Michael C.; Walston, Jeremy D.; Hughes, Jennifer M.; Carey, John P.

doi:10.1097/mao.0b013e3182545061

Cited by 158 publications

(139 citation statements)

References 31 publications

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“…N1 amplitudes were used in oVEMP analyses, and peak-to-peak amplitudes were used in cVEMP analyses, as specified in the text. observed significant decreases in cVEMP peak-to-peak amplitudes but not oVEMP n1 amplitudes with increasing age, as has been reported previously (Agrawal et al 2012).…”

Section: Resultssupporting

confidence: 72%

Clinical Testing of Otolith Function: Perceptual Thresholds and Myogenic Potentials

Agrawal

Bremova-Ertl

Kremmyda

et al. 2013

JARO

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Cervical and ocular vestibular-evoked myogenic potential (cVEMP/oVEMP) tests are widely used clinical tests of otolith function. However, VEMP testing may not be the ideal measure of otolith function given the significant inter-individual variability in responses and given that the stimuli used to elicit VEMPs are not physiological. We therefore evaluated linear motion perceptual threshold testing compared with cVEMP and oVEMP testing as measures of saccular and utricular function, respectively. A multi-axis motion platform was used to measure horizontal (along the inter-aural and nasooccipital axes) and vertical motion perceptual thresholds. These findings were compared with the vibration-evoked oVEMP as a measure of utricular function and soundevoked cVEMP as a measure of saccular function. We also considered how perceptual threshold and cVEMP/ oVEMP testing are each associated with Dizziness Handicap Inventory (DHI) scores. We enrolled 33 patients with bilateral vestibulopathy of different severities and 42 controls to have sufficient variability in otolith function. Subjects with abnormal oVEMP amplitudes had significantly higher (poorer) perceptual thresholds in the inter-aural and naso-occipital axes in age-adjusted analyses; no significant associations were observed for vertical perceptual thresholds and cVEMP amplitudes.Both oVEMP amplitudes and naso-occipital axis perceptual thresholds were significantly associated with DHI scores. These data suggest that horizontal perceptual thresholds and oVEMPs may estimate the same underlying physiological construct: utricular function.

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Section: Resultssupporting

confidence: 72%

Clinical Testing of Otolith Function: Perceptual Thresholds and Myogenic Potentials

Agrawal

Bremova-Ertl

Kremmyda

et al. 2013

JARO

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“…Aging has been associated with reduction in otoconia mass as well as fracture and fragment formation in both animals and humans (31)(32)(33)(34)(35). While it is easy to assume that reduction in otoconia would result in the reduction of organ function, otoconia degeneration has been shown to affect the utricle more than the saccule (31, 36), which would not explain the findings in the Agrawal et al study (27). In contrast, it has been previously reported that, while hair loss occurs in all the peripheral vestibular organs with increasing age, the utricle is relatively spared (17).…”

Section: Otolith Organscontrasting

confidence: 54%

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Agrawal¹,

Carey²

2017

Frontiers Research Topics

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The vestibular system sub-serves a number of reflex and perceptual functions, comprising the peripheral apparatus, the vestibular nerve, the brainstem and cerebellar processing circuits, the thalamic relays, and the vestibular cerebral cortical network. This system provides signals of self-motion, important for gaze and postural control, and signals of traveled distance, for spatial orientation, especially in the dark. Current evidence suggests that certain aspects of this multi-faceted system may deteriorate with age and sometimes with severe consequences, such as falls. Often the deterioration in vestibular functioning relates to how the signal is processed by brain circuits rather than an impairment in the sensory transduction process. We review current data concerning age-related changes in the vestibular system, and how this may be important for clinicians dealing with balance disorders.

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“…These results suggest that the function of the otolith organs as well as their central pathway also deteriorate with increasing age. Recently, Agrawal et al (2012) measured the function of the semicircular canals, utricle, and saccule using the head thrust test, oVEMP, and cVEMP, respectively, in healthy subjects more than 70 years old [55]. They showed that the function of the semicircular canals as well as the otolith organs decline with age, although the magnitude of impairment was greater for the semicircular canals than the otolith organs.…”

Section: Functional Deterioration Of Vestibular Systems In the Elderlymentioning

confidence: 99%

Dizziness and Imbalance in the Elderly: Age-related Decline in the Vestibular System

Iwasaki¹,

Yamasoba²

2015

Aging and disease

236

173

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Decline in Semicircular Canal and Otolith Function With Age

Cited by 158 publications

References 31 publications

Clinical Testing of Otolith Function: Perceptual Thresholds and Myogenic Potentials

Clinical Testing of Otolith Function: Perceptual Thresholds and Myogenic Potentials

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Dizziness and Imbalance in the Elderly: Age-related Decline in the Vestibular System

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