Decline in Infantile Hypertrophic Pyloric Stenosis in Germany in 2000–2008

Laffolie, Jan de; Turial, Salmai; Heckmann, Matthias; Zimmer, Klaus–Peter; Schier, Felix

doi:10.1542/peds.2011-2845

Cited by 42 publications

(43 citation statements)

References 18 publications

(19 reference statements)

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“…In this study and in our previously presented data, we found high variability over different regions and time periods in Germany, and the significant decline in IHPS incidence observed for all of Germany was noted to reflect a decline in nearly all individual regions [10].…”

Section: Discussionsupporting

confidence: 75%

“…For example, in a large study conducted in California, for children born to mothers who were 35 years of age or greater, there was no significant role for birth rank [12]. In this study, data from German regions on maternal age and history of migration (as a surrogate for ethnicity) were analyzed to explain the observed decline in IHPS incidence in the period from 2000-2008 [10].…”

mentioning

confidence: 96%

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Correlation of Maternal Age and Migration on IHPS Epidemiology in Germany 2000-2008

Laffolie

Faas²,

Hirschburger³

et al. 2014

Epidemiol

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A decline in the incidence of infantile hypertrophic pyloric stenosis (IHPS) was recently reported in Sweden, the US, Denmark, Scotland, and Germany. Data to explain this phenomenon, however, are scarce.Given our previous epidemiologic data showing a decline in the incidence of IHPS, we collected data on maternal age and history of migration from regional administrative centers to obtain data that might support an explanation for our previous findings. We examined the correlation between these factors and the incidence of IHPS.Data were extracted from the public report of health (Gesundheitsberichterstattung des Bundes) and population data from federal state governments. We obtained the numbers of IHPS (ICD-10 code 40.0) and live births in each federal state for the period 2000-2008. Further data were collected from federal state administrative agencies on age of the mother at the birth of their first child and history of migration for all mothers at first birth.There were significant differences in the regional distribution of both variables and the variability of these factors over time. Average maternal age and the percentage of mothers with a history of migration showed a negative correlation with the regional incidence of infantile hypertrophic pyloric stenosis. Conclusion:The wide variation in the incidence of infantile hypertrophic pyloric stenosis over time and for different regions is significantly inversely correlated with rising maternal age and the percentage of mothers with a history of migration.

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Section: Discussionsupporting

confidence: 75%

mentioning

confidence: 96%

Correlation of Maternal Age and Migration on IHPS Epidemiology in Germany 2000-2008

Laffolie

Faas²,

Hirschburger³

et al. 2014

Epidemiol

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show abstract

“…28 Second, the IHPS risk associated with bottle-feeding 6;7 could in part be caused by insufficient lipid levels since bottle-feeding is known to be associated with lower total and LDL cholesterol levels in infancy. 29 Finally, the drop in IHPS incidence observed in the 1990s in several countries 8;30–33 coincided temporally with increasing percentages of mothers breastfeeding their infants 34 , suggesting that better nutritional status in infants may have prevented IHPS from developing in a fraction of potential cases.…”

Section: Commentmentioning

confidence: 97%

Plasma Lipids, Genetic Variants NearAPOA1, and the Risk of Infantile Hypertrophic Pyloric Stenosis

Feenstra

Geller

Carstensen

et al. 2013

JAMA

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“…Regardless of the etiological debates [17][18][19][20], typically infants with IHPS are clinically normal at birth but during the first few weeks of postnatal life, they develop nonbilious forceful vomiting mostly described as "projectile". Gastric outlet obstruction leads to emaciation and, if left untreated, may result in death [1,21,22].…”

Section: Discussionmentioning

confidence: 99%

The use of ultrasonography in infantile hypertrophic pyloric stenosis: do the patientâ€™s age and weight affect pyloric size and pyloric ratio?

et al. 2015

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Aims: We aimed to obtain pyloric measurements of our patients with infantile hypertrophic pyloric stenosis (IHPS) using ultrasonography (US) and to evaluate the correlations between age, weight and pyloric size, pyloric ratio (PR). Material and methods: We designed a retrospective study including 20 term infants with surgically proven IHPS and studied the ultrasonographically obtained pyloric muscle thickness (PMT), pyloric diameter (width) (PD), pyloric length (PL) and PR (PMT/PD) to determine if there were statistically significant associations between patient age/weight and pyloric measurements. Results: The mean age of the infants was 38.7±17.3 days (range, 9-76 days) and their mean weight was 3688.5±772.7 g (range, 2810-6000 g), at referral. Mean PMT was 4.98±1.04 mm (range, 3.5-6.8 mm). Mean PD was 14.04±2.39 mm (range, 10-18 mm). Mean PL was 22.16±4.02 mm (range, 16-31.5 mm) and mean PR was 0.35±0.04 (range, 0.29-0.42). The correlation between age and PMT (r=0.654, p<0.05) and the correlation between age and PD (r=0.747, p <0.05) were significant. Age and weight were not significantly correlated with PR (p>0.05). Conclusions: The PMT and PD are age dependent parameters. The PR is age and weight independent and therefore, when combined with PMT, PD and PL, it can be useful in the diagnosis of IHPS in infants with early onset disease and/or in those with a lower weight.

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Decline in Infantile Hypertrophic Pyloric Stenosis in Germany in 2000–2008

Abstract: The IHPS incidence declined by ∼38% nationwide. A parallel decline in SIDS displayed a different pattern in regional distribution; thus, a common cause was unlikely. The regional differences indicated that etiologic factors remained unresolved.

Cited by 42 publications

References 18 publications

Correlation of Maternal Age and Migration on IHPS Epidemiology in Germany 2000-2008

Correlation of Maternal Age and Migration on IHPS Epidemiology in Germany 2000-2008

Plasma Lipids, Genetic Variants NearAPOA1, and the Risk of Infantile Hypertrophic Pyloric Stenosis

The use of ultrasonography in infantile hypertrophic pyloric stenosis: do the patientâ€™s age and weight affect pyloric size and pyloric ratio?

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