This chapter presents a summary of major applications in numerical oil spill predictions for the Eastern Mediterranean Sea. Since the trilateral agreement between Cyprus, Egypt, and Israel back in 1997, under the framework of the subregional contingency plan for preparedness and response to major oil spill pollution incidents in the Eastern Mediterranean Sea, several oil spill models have been implemented during real oil pollution accidents and after oil spills that were detected from satellite remote sensing SAR data. In addition, several projects cofinanced by the European Commission addressed particularly issues with oil spill