Decision-support challenges in the chemical-pharmaceutical industry: Findings and future research directions

Marques, Catarina M.; Moniz, Samuel; Sousa, Jorge Pinho de; Barbosa‐Póvoa, Ana Paula; Reklaitis, Gintaras V.

doi:10.1016/j.compchemeng.2019.106672

Cited by 38 publications

(17 citation statements)

References 220 publications

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“…Considering the industrial location theory and referring to existing research results [32,37,38,40,41,[59][60][61][62][63][64], seven influencing factors-resource conditions, port conditions, geographic location, foreign investment, investment in science and technology, market demand, and environmental regulations-based on the representativeness of the indicators and data availability were included in the regression analysis (Table 1). e chemical industry is a distinct resource-dependent industry that also depends on port transportation [13,20]. It follows the general law of CIC distribution around coastal areas and large rivers [13].…”

Section: Analyzing the Influencing Factors Of Cic Developmentmentioning

confidence: 99%

“…ese industries have different industrial sectors and varied reasons for driving the industrial chain [9,10]. Because of the varied industrial sectoral structures, there are different divisions of labor and cooperation models in the development of the urban chemical industry [11,12], which have led to different product characteristics and industrial chains [13].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Classification and Restructuring of Chemical Industrial Cities in China: The Perspectives of Sectoral and Spatial Differences

et al. 2021

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As an economic pillar, major resource consumer, and polluter of cities, the chemical industry determines many cities’ transformation, prosperity, and decay. It is thus a major concern for achieving the UN Sustainable Development Goals. In China, which is at the stage of accelerated industrialization that is varied across regions, the chemical industry has gradually retreated from developed cities, such as Beijing and Shanghai, in the eastern region, and has become the inevitable choice for industrialization of less-developed cities, such as Xi’an, Chengdu, and Chongqing, in the western region. This study took the perspectives of chemical industrial sectors and their spatial differences to understand the changing patterns of the chemical industry and its dominant cities. It identified chemical industrial cities (CICs), examined their spatial-temporal patterns with respect to their industry scale and structure, and accounted for factors influencing the spatial evolution from coastal areas to inland regions. The results show that large CICs were mainly located in coastal port regions with balanced industrial sectors, while small CICs were mainly distributed in inland areas with abundant oil and coal resources and a single dominant industrial sector. The location factors of ports, markets, and technology play important roles in the eastern region, while resource conditions and foreign direct investment promote the chemical industry’s development in the central, western, and northeastern cities. These findings improve the understanding of CICs’ spatial transformation and shed light on the policy-making of chemical industrial development in China and other developing countries.

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Section: Analyzing the Influencing Factors Of Cic Developmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Classification and Restructuring of Chemical Industrial Cities in China: The Perspectives of Sectoral and Spatial Differences

et al. 2021

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“…Large R&D multinationals are the key players in the marketplace, with presence in branded products and manufacturing sites across many locations. In recent years, their research focus has shifted to unmet needs of smaller patient populations, such as prevention and cure of rare diseases [46]. The increasing complexity of novel targeted therapeutics and lack of in-house manufacturing expertise of large multinationals in these contexts have determined an increased in mergers and acquisition (M&A) and outsourcing strategies through CMOs or CDMOs [46].…”

Section: New Playersmentioning

confidence: 99%

“…In recent years, their research focus has shifted to unmet needs of smaller patient populations, such as prevention and cure of rare diseases [46]. The increasing complexity of novel targeted therapeutics and lack of in-house manufacturing expertise of large multinationals in these contexts have determined an increased in mergers and acquisition (M&A) and outsourcing strategies through CMOs or CDMOs [46]. For instance, CellforCure was acquired by Novartis, expanding the company's manufacturing capabilities in CAR-T cell therapies, Hitachi acquired Aptech to increase manufacturing capabilities in Europe, Thermo Fisher acquire CMO Brammer Bio for $1.7 bn and GE Healthcare was acquired by Danaher ($21.4 bn) [43].…”

Section: New Playersmentioning

confidence: 99%

“…Process systems engineering (PSE) has been traditionally assisting decision making in the pharmaceutical industry [46,[65][66][67][68]. The adoption of digitalisation in pharmaceutical manufacturing and the supply chain will be key for seamless data exchange across manufacturing facilities and supply chain networks, as it will allow connectivity of processes, products, and people.…”

Section: Assisting Digitalisation In Pharmaceutical Industry Via Procmentioning

confidence: 99%

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Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution

et al. 2021

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The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for seamless communication between process units, plants, and distribution nodes. In this paper, we discuss how novel therapeutics of high-specificity and sensitive nature are reshaping well-established paradigms in the pharmaceutical industry. We present an overview of recent research directions in pharmaceutical manufacturing and supply chain design and operations. We discuss topical challenges and opportunities related to small molecules and biologics, dividing the latter into patient- and non-specific. Lastly, we present the role of process systems engineering in generating decision-making tools to assist manufacturing and distribution strategies in the pharmaceutical sector and ultimately embrace the benefits of digitalised operations.

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Triggers for chemical product design: A systematic literature review

et al. 2022

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The product design project is a complex problem because objectives and constraints must be considered simultaneously, the sustainability context is highly relevant and specific, decision‐making involves not only customer needs but also of other stakeholders, especially the organization in which the design project takes place. This work presents a systematic literature review of design methodologies for chemical products to identify how that problem has been addressed and which are the future challenges to be met. The review involved the analysis of 262 research papers and 336 patents, classified according to the chemical product type, the design phase studied, and whether they consider association with a business context. The study highlights the need for holistic product design methodologies applicable from the early design stages, covering the assessment of customer needs and the requirements of other stakeholders, as well as the business context where the design process is carried out.

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Decision-support challenges in the chemical-pharmaceutical industry: Findings and future research directions

Cited by 38 publications

References 220 publications

Exploring the Classification and Restructuring of Chemical Industrial Cities in China: The Perspectives of Sectoral and Spatial Differences

Exploring the Classification and Restructuring of Chemical Industrial Cities in China: The Perspectives of Sectoral and Spatial Differences

Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution

Triggers for chemical product design: A systematic literature review

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