Aiming at some disadvantages in calculus teaching, this paper summarizes the important significance of the reform of calculus teaching, and mainly discusses some measures of reform from the aspects of teaching content, teaching method, and teaching evaluation method. It is pointed out that the teaching of calculus should be based on modern educational technology, combine with the teaching of digital information, and the idea of mathematical modeling should be introduced into the classroom, which are effective ways to reform the teaching of calculus in colleges and universities.