Decision-making process related to treatment and management in Korean women with breast cancer: Finding the right individualized healthcare trajectory

Kim, Kkotbong; Yang, Jinhyang

doi:10.1016/j.apnr.2017.02.022

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Meanwhile, it is difficult to separate credible from untrustworthy online information. While patients who lack the ability to identify specialized information are prone to experience informational confusion, the key phases of the decision-making process require them to weigh the pros and cons of each option based on their own circumstances 14 in order to make the optimal choice. However, healthcare providers at public hospitals are often preoccupied with work and have insufficient time to communicate with patients, likely resulting in an understanding gap between them during the decision-making process—a finding in line with those of recent studies.…”

Section: Discussionmentioning

confidence: 99%

Shared Decision-Making in Hemophilic Arthropathy Rehabilitation: A Qualitative Study

Liu

Guo

et al. 2023

PPA

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Purpose To probe into the needs and barriers underlying patients’ participation in shared decision-making related to rehabilitation nursing for hemophilic arthropathy. Patients and Methods The phenomenological research approach was adopted to conduct a series of semi-structured, in-depth interviews with 15 patients with hemophilic arthropathy undergoing rehabilitative treatments, 10 caregivers, and 7 healthcare providers from a hemophilia treatment center in Shanxi province, China. Colaizzi’s seven-step method of data analysis was applied to organize, analyze, and extract the themes from the interview materials. Results Three main themes emerged from the analysis: the status quo of the healthcare system (insufficient decision support systems and mismatch between healthcare providers’ and patients’ resources), circumstances of provider–patient interactions (lack of information exchange and unbalanced power structure between healthcare providers and patients), and patient-related factors influencing participation in decision-making (lack of self-efficacy, personal characteristics, family and social decision support, and attitude toward participation in decision-making). Conclusion Participation in rehabilitation decision-making among patients with hemophilic arthropathy is affected by multiple barriers. Healthcare professionals should improve their understanding of shared decision-making, offer patients active guidance on participating in the decision-making process, prioritize their affective needs, and formulate professional and effective solutions to support shared decision-making as early as possible.

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Section: Discussionmentioning

confidence: 99%

Shared Decision-Making in Hemophilic Arthropathy Rehabilitation: A Qualitative Study

Liu

Guo

et al. 2023

PPA

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Systematic screening of protein-coding gene expression identified VWF as a potential key regulator in anthracycline-based chemotherapy-exacerbated metastasis of breast cancer

Zhao,

He,

Cui

et al. 2024

BMC Cancer

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Background Breast cancer is the most commonly diagnosed cancer worldwide. Although major treatments represented by chemotherapy have shown effectiveness at the initial period, recurrence and metastasis still occur later after treatments. The alternation of the tumor microenvironment by chemotherapy is confirmed as a trigger of the elevated proliferation and migration of the remaining tumor cells. Methods Using bioinformatic methods, differential gene expression analysis was used to determine DEGs between post-chemotherapy and pre-chemotherapy samples of breast cancer patients, followed by survival analysis and ELISA analysis of the potential key genes. An in vitro model of 2 breast cancer cells lines was used to demonstrate the role of VWF in the evasion and migration of breast cancer cells, using cell migration, evasion and wound healing assays, PCR and molecular docking analysis. Results 19 hub genes were further identified using GO and KEGG pathway analyses and WGCNA. The 5 secreted protein-coding genes with reported carcinogenesis effects (VWF, SVEP1, DPT, ADIPOQ, and LPL) were further analyzed in breast cancer patients and VWF was identified as a potential key regulator in the anthracycline-based chemotherapy-exacerbated metastasis. It was further confirmed that anthracycline-based chemotherapeutics doxorubicin exacerbated VWF upregulation and the evasion and migration of breast cancer cells. Based on molecular docking analysis and previous study, berberine was used as an inhibitor of VWF, and showed an effective inhibition of the doxorubicin-exacerbated VWF upregulation, migration and evasion in breast cancer. Conclusions Doxorubicin-exacerbated evasion and migration through VWF upregulation. Berberine as an inhibitor of VWF was able to reversed the doxorubicin-exacerbated VWF upregulation and evasion and migration in breast cancer cells. Supplementary Information The online version contains supplementary material available at 10.1186/s12885-024-12999-9.

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Decision-making process related to treatment and management in Korean women with breast cancer: Finding the right individualized healthcare trajectory

Cited by 2 publications

References 17 publications

Shared Decision-Making in Hemophilic Arthropathy Rehabilitation: A Qualitative Study

Shared Decision-Making in Hemophilic Arthropathy Rehabilitation: A Qualitative Study

Systematic screening of protein-coding gene expression identified VWF as a potential key regulator in anthracycline-based chemotherapy-exacerbated metastasis of breast cancer

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