Decision‐making in Parkinson’s disease patients with and without pathological gambling

Rossi, Malco; Gerschcovich, Eliana Roldan; Achával, Delfina de; Pérez-Lloret, Santiago; Cerquetti, Daniel; Cammarota, Angel; Nouzeilles, María Inés; Fahrer, Rodolfo; Merello, Marcelo; Leiguarda, R

doi:10.1111/j.1468-1331.2009.02792.x

Cited by 104 publications

(96 citation statements)

References 38 publications

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“…Compared to PD patients without impulse control disorder (ICDs), PD patients with pathological gambling (PG) showed impaired cognitive impulsivity, i.e. poorer performances on the IGT [66], and preference for immediate over future rewards [67]. Neuroimaging studies have underlined the idea of a susceptibility to impulsivity.…”

Section: Cognitive Impulsivity In Parkinson's Diseasementioning

confidence: 99%

Impulsivity and Parkinson's disease: More than just disinhibition

Antonelli

Ray

Strafella

2011

Journal of the Neurological Sciences

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In the last few years it has become clear that impulsivity is a complex behaviour composed of different domains and dependent on different neural networks. The proposed pathogenetic mechanisms for the emergence of impulsivity disorders in Parkinson's Disease (PD) can be broadly separated into three potentially interacting processes: the contribution of premorbid susceptibility to impulsivity, the contribution of the disease itself to the behaviour and the potential contribution of therapeutic agents. Growing evidence suggests that dopamine and the subthalamic nucleus are playing a certain role in the pathophysiology of different aspects of impulsivity. In this review, we summarise the main concepts defining various components of impulsivity both in healthy subjects and patients affected by PD.

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Section: Cognitive Impulsivity In Parkinson's Diseasementioning

confidence: 99%

Impulsivity and Parkinson's disease: More than just disinhibition

Antonelli

Ray

Strafella

2011

Journal of the Neurological Sciences

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“…In a recent study of PD patients with and without an ICD, patients with ICDs demonstrated intact stimulus reinforcement learning, but had a strong preference for immediate over future rewards using the delayed discounting task [41]. In a study using the Iowa Gambling Task, PD patients with PG demonstrated greater impairment in decision making compared with PD controls [42]. Another study of PD patients with and without ICD tested on versus off DA treatment reported that only ICD patients demonstrated increased risk taking on the Balloon Analogue Risk Task with DA exposure [43].…”

Section: Cognitive Performance Of Pd Patients With Icdsmentioning

confidence: 99%

Impulse Control and Related Disorders in Parkinson’s Disease

Weintraub

Nirenberg

2012

Neurodegener Dis

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Impulse control disorders (ICDs), such as compulsive gambling, buying, sexual behavior, and eating, are a serious and increasingly recognized complication of dopamine replacement therapy in Parkinson’s disease (PD). Other impulsive-compulsive behaviors have been linked to dopaminergic medications; these include punding (stereotyped, repetitive, purposeless behaviors) and dopamine dysregulation syndrome (DDS; compulsive medication overuse). ICDs have been most closely related to the use of dopamine agonists (DAs), particularly at higher dosages; in contrast, DDS is primarily associated with shorter-acting, higher-potency dopaminergic medications, such as apomorphine and levodopa. Risk factors for ICDs may include male sex; younger age; younger age at PD onset; a pre-PD history of ICD(s); personal or family history of substance abuse; bipolar disorder; gambling problems; and impulsive personality traits. The primary treatment of ICDs in PD is discontinuation of DA therapy. Not all patients can tolerate this, however, due to worsening motor symptoms and/or DA withdrawal syndrome (a severe, stereotyped drug withdrawal syndrome similar to that of other psychostimulants). While psychiatric medications are frequently used to treat ICDs in the general population, there is no empirical evidence to suggest that they are effective in PD. Given the paucity of treatment options and potentially serious consequences of ICDs in PD, it is critical for patients to be monitored closely for their development. As empirically validated treatments for ICDs emerge, it will also be important to examine their efficacy and tolerability in individuals with comorbid PD.

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“…This is in contrast to PD patients without ICBs who are usually risk averse, anhedonic and low in novelty seeking [42][43][44][45][46]. PD patients with ICB are more aggressive, disinhibited and more antisocial than control PD patients [7,33,47]. Further they have higher schizotypy scores, which measures the risk of psychosis, compared to controls [48].…”

Section: Personality Traits Decision-making and Reward Processing Inmentioning

confidence: 85%