Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive–compulsive disorder

Positive association between MET allele (BDNF Val66Met polymorphism) and obsessive-compulsive disorder

“…2,3 Moreover, OCD is a spectrum disorder with multiple genes involved, each of which contributing only a small fraction to the overall risk. [2][3][4][5] The importance of homogeneous patient groups is exemplified by recent reports that have demonstrated the association between Met allele and the early onset of OCD in males, similarly to the association between the Val66Val genotype and the Val allele in males and OCD patients with sexual/religious obsessions. Furthermore, Met66Met genotype has been previously associated to mild OCD in female patients.…”

“…Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric condition. [2][3][4][5] Considering that the serotonin system plays an important role in the pathogenesis of OCD, the BDNF gene is an interesting candidate gene for OCD. 4,5 BDNF Val66Met is a polymorphism that has been widely investigated in psychiatric disorders.…”

“…[2][3][4][5] Considering that the serotonin system plays an important role in the pathogenesis of OCD, the BDNF gene is an interesting candidate gene for OCD. 4,5 BDNF Val66Met is a polymorphism that has been widely investigated in psychiatric disorders. The Met allele of the BDNF Val66Met polymorphism is associated with reduced BDNF activity and harm avoidance, and it has been suggested that it may be associated with depression, schizophrenia, bipolar disorder and OCD, although findings have been inconsistent.…”

The Roles of Dopamine and Serotonin in Decision Making: Evidence from Pharmacological Experiments in Humans

“…Thus, carriers of the ss allele of the 5-HTTPLR gene have shown enhanced attention toward probability cues during the performance of a risky choice task compared with carriers of the ll allele (Roiser et al, 2006), fewer risky choices in a financial investment task (Kuhnen and Chiao, 2009), and smaller impairments in probabilistic reversal tasks following tryptophan depletion (Finger et al, 2007), especially under aversive reinforcement conditions (Blair et al, 2008). Notably, female ss carriers have also shown poorer decisions under conditions of decision ambiguity (Stoltenberg and Vandever, 2010), poor performance of the Iowa gambling game compared with carriers of the ll allele (Homberg et al, 2008), and especially in OCD samples (da Rocha et al, 2008).…”

Comportamento anti-social e impulsividade no transtorno de personalidade anti-social

“…A impulsividade é frequentemente observada nesses indivíduos e pode ser definida, basicamente, como uma predisposição para reações rápidas e não planejadas a estímulos externos ou internos, sem que sejam avaliadas as possíveis consequências de tais comportamentos 2 . A impulsividade é associada com disfunção do sistema serotonérgico e do córtex pré-frontal e suas conexões, alterações já observados no TPAS por meio de exames de neuroimagem, genéticos e neuropsicológicos [2][3][4][5] . A relação entre a impulsividade e as diversas variáveis comportamentais como, por exemplo, o início dos atos criminosos, é pouco explorada na literatura e pode contribuir para uma melhor compreensão do transtorno e na elaboração de planos terapêuticos mais específicos [2][3][4] .…”