Decision making guided by emotion

Béroule, Dominique; Gisquet-Verrier, Pascale

doi:10.1109/ijcnn.2012.6252412

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…Compared to a previous set of experiments in which no global internal state was modeled [30], propagation is even more focused, with only 3% of epus activated above their thresholds in both C2 1 and C3 1 . Although less rein forcers are anticipated because of this 'motivational' effect, one third of C1 1 and almost two thirds of C2 2 participate in action selection, which shows the prevalence of emotional channels activity.…”

Section: Rate Of Active Epus During a Testing Trialmentioning

confidence: 58%

“…First investigated in non-human primates, this model is supported by brain imaging studies in humans, which enhances the notion that cortical regions are functionally linked through a cascade of interactions [29]. A similar functional organization has recently been drafted in the form of GP computational architecture [30]. An updated version of this deterministic system generates here a main neurobiological hypothesis to account for fast action-selection: when a given cue occurs, neuromodulator is assumed to selectively boost the spontaneous activity propagating down memory paths of the cortico-striatal areas, so as to enable the anticipation of relevant emotional events.…”

Section: Introductionmentioning

confidence: 85%

“…Two options have been considered so far to oppose this dysfunction: 1/ To depress the level-1 modulation controlling the cue-induced prediction of an immediate drug-like reward [30] 2/ To perform counter-conditioning by conducting another training session in which the extreme reinforcer is replaced by another one of the same high intensity but opposite sign.…”

Section: Adding Extreme Stimuli To Datamentioning

confidence: 99%

“…Previous GPS experiments [30] also showed that 2 nd -order conditioning could be simulated by assigning the label of an often used emotional cue to a new DE at the top of the Emotion-detector channel. This solution comes from the availability of a pool of epus for extending Detectors/ Effectors banks.…”

Section: Behavioral Featuresmentioning

confidence: 99%

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A Functional Model of Fast Action Selection Guided by Emotional Stimuli

Béroule

Verrier²

2016

Int J Swarm Intel Evol Comput

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Section: Rate Of Active Epus During a Testing Trialmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 85%

Section: Adding Extreme Stimuli To Datamentioning

confidence: 99%

Section: Behavioral Featuresmentioning

confidence: 99%

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A Functional Model of Fast Action Selection Guided by Emotional Stimuli

Béroule

Verrier²

2016

Int J Swarm Intel Evol Comput

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Memory reactivation effects independent of reconsolidation

Gisquet-Verrier¹,

Riccio²

2012

Learn. Mem.

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Memory reactivation is an important process resulting from reexposure to salient training-related information whereby a memory is brought from an inactive to an active state. Reactivation is the first stage of memory retrieval but can result from the exposure to salient cues without any behavioral output. Such cue-induced reactivation, although frequently used by neuroscientists to study reconsolidation, has seldom been considered as a process in its own right and studied as such. This review presents arguments indicating that memory reactivation has two main consequences: (1) to enhance the accessibility of the target memory and (2) to make the memory malleable. Accordingly, reactivation creates a transient state during which the content of the memory is easily accessible and can be modified and/or updated. As both of these aspects can be observed shortly after memory reactivation, this review emphasizes that reconsolidation is not necessarily required for these processes and calls attention to reactivation as a factor in the dynamics of the memory.Memory retrieval is a complex (multistage) process through which previously acquired information can be used, leading to a behavioral output. Memory reactivation is the first component of retrieval corresponding to the process through which a memory is triggered from a latent state to a state in which it can be retrieved. Reactivation is generated by cues that are either external or self-generated and occurs in two general conditions. First, reactivation is required for retrieval and for every operation that enlarges or modifies previous knowledge. This includes retraining, when coherent supplementary information is provided, extinction when the previously learned response is no longer reinforced, and more generally, all rule-shiftings, i.e., when the contingency governing the response is changed. As a result, reactivation is largely embedded with retrieval and this probably explains why these two terms are often used interchangeably in the literature.

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Offline encoding impaired by epigenetic regulations of monoamines in the guided propagation model of autism

Béroule

2018

BMC Neurosci

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Background Environmental factors can modify the expression of genes, including those involved in the metabolism of neurotransmitters. Accounting for a control role of monoamine neurotransmitters, the guided propagation (GP) memory model may contribute to investigate the consequences of neuromodulation impairments on development disorders such as autism. A prenatal transient excess of ‘monoamine oxidase A’ enzyme is assumed here to trigger persistent epigenetic regulations that would induce imbalanced metabolisms of synaptic monoamines. When imported into the ‘offline’ encoding cycles of a GP model, the consequent ‘serotoninergic noise’ leads to aberrant memory structures that can be linked with autism symptoms.ResultsIn computer experiments, different levels of uncoupling between representations of monoamines correlate with the amount of impaired GP modules, the severity of irrelevant connections, as well as network overgrowth. Two types of faulty connections are respectively assumed to underlie autism traits, namely repetitive behavior and perceptual oversensitivity. Besides computational modelling, a genetic family-tree shows how the autism sex-ratio can result from combinations of pharmacological and epigenetic features.ConclusionsThese results suggest that the current rise of autism is favored by three possible sources of biological masking: (1) during sleep, when cyclic variations of monoamines may undergo disrupted enzymatic activities; (2) across generations of ‘healthy carriers’ protected by the X-chromosome silencing and a specific genetic variant; (3) early in life, as long as the brain development draws on pools of neurons born when the transient enzymatic excess and its persistent epigenetic regulation overlapped, and as long as the B type of monoamine oxidase does not significantly impact dopamine. A disease-modifying therapy can be derived from this study, which involves relevant biomarkers to be first monitored over several months of clinical trial.Electronic supplementary materialThe online version of this article (10.1186/s12868-018-0477-1) contains supplementary material, which is available to authorized users.

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Decision making guided by emotion

Cited by 3 publications

References 23 publications

A Functional Model of Fast Action Selection Guided by Emotional Stimuli

A Functional Model of Fast Action Selection Guided by Emotional Stimuli

Memory reactivation effects independent of reconsolidation

Offline encoding impaired by epigenetic regulations of monoamines in the guided propagation model of autism

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