Abstract:As phages are extensively investigated as novel therapy tools but also as transfer agents for antibiotic resistance genes, thorough understanding of phage-host interactions becomes crucial. Prerequisite for phage infection is its adhesion to the host surface. Here, we used atomic force microscopy-based singleparticle force spectroscopy with phage-decorated tips to decipher the adhesion of phage 187 on living Staphylococcus aureus cells. We found that addition of free N-acetyl-D-glucosamine was able to decrease… Show more
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