Deciphering the Mystery in p300 Taz2–p53 TAD2 Recognition
Tongtong Li,
Stefano Motta,
Yi He
Abstract:Intrinsically disordered proteins (IDPs) engage in various
fundamental
biological activities, and their behavior is of particular importance
for a better understanding of the verbose but well-organized signal
transduction in cells. IDPs exhibit uniquely paradoxical features
with low affinity but simultaneously high specificity in recognizing
their binding targets. The transcription factor p53 plays a crucial
role in cancer suppression, carrying out some of its biological functions
using its disordered regions,… Show more
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