Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy
Diana Tavares Ferreira,
Breanna Q Shen,
Juliet M Mwirigi
et al.
Abstract:Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus that is caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight into the disease process using bulk and spatial RNA sequencing on tibial and sural nerves recovered from lower leg amputations in a mostly diabetic population. First, our approach comparing mixed sensory and motor tibial and purely sensory sural nerves shows key pathway differences in affected nerves, with distinct immunologica… Show more
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