Deciphering the influence of centrosome-related genes on osteosarcoma to develop a prognostic signature
Yujian Zhong,
Sixing Wei,
Xiaoshuang Zeng
et al.
Abstract:The centrosome, a vital component in mitosis in eukaryotes, plays a pivotal role in cancer progression by influencing the proliferation and differentiation of malignant cells, making it a significant therapeutic target. We collected genes associated with centrosomes from existing literature and established a prognostic model for 85 osteosarcoma patients from the TARGET database. Genes associated with prognosis were identified through univariate Cox regression. We then mitigated overfitting by addressing collin… Show more
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