Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry

Xu, Xiaobin; Zhang, Aming; Xu, Yan; Cao, Yuan; Cale, Stephen; Franklin, Matthew C.; Sarangapani, Prasad; Ihnát, Peter; Qiu, Haibo; Liu, Dingjiang; Pyles, Erica; Shameem, Mohammed; Li, Ning

doi:10.1016/j.xphs.2021.12.027

Journal of Pharmaceutical Sciences

2022

DOI: 10.1016/j.xphs.2021.12.027

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Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry

Xiaobin Xu

Aming Zhang

Yan Xu

et al.

Abstract: Deciphering the high viscosity of a therapeutic monoclonal antibody in high concentration formulations by microdialysishydrogen/deuterium exchange mass spectrometry,

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From cell factories to patients: Stability challenges in biopharmaceuticals manufacturing and administration with mitigation strategies

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et al. 2023

International Journal of Pharmaceutics

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From cell factories to patients: Stability challenges in biopharmaceuticals manufacturing and administration with mitigation strategies

Elsayed,

Jaber,

Al-Remawi

et al. 2023

International Journal of Pharmaceutics

View full text Add to dashboard Cite

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Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry

Abstract: Deciphering the high viscosity of a therapeutic monoclonal antibody in high concentration formulations by microdialysishydrogen/deuterium exchange mass spectrometry,

Cited by 1 publication

References 59 publications

From cell factories to patients: Stability challenges in biopharmaceuticals manufacturing and administration with mitigation strategies

From cell factories to patients: Stability challenges in biopharmaceuticals manufacturing and administration with mitigation strategies

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