Deciphering programmed cell death mechanisms in osteosarcoma for prognostic modeling
Jingyang Chen,
Tengdi Fan,
Lingxiao Pan
et al.
Abstract:Osteosarcoma (OS), known for its high recurrence and metastasis rates, poses a significant challenge in oncology. Our research investigates the role of programmed cell death (PCD) genes in OS and develops a prognostic model using advanced bioinformatics. We analyzed single‐cell sequencing data from the Gene Expression Omnibus (GEO) database to identify subpopulations, distinguish malignant from non‐malignant cells, assess cell cycle phases, and map PCD gene distribution. Additionally, we applied consistency cl… Show more
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