Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
Carolin Bokelmann,
Alireza Ehsani,
Jochen Schaub
et al.
Abstract:Due to their high specificity, monoclonal antibodies (mAbs) have garnered significant attention in recent decades, with advancements in production processes, such as high seeding density (HSD) strategies, contributing to improved titers. This study provides a thorough investigation of high seeding processes for mAb production in Chinese hamster ovary (CHO) cells. Using a metabolic network and flux balance analysis, we compared standard fed-batch (STD FB) with HSD cultivations, exploring supplementary lactate a… Show more
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