“…Gene expression in BM-MSCs, HSCs, lymphocytes, fibroblasts, and osteoblasts has been used to create regulatory gene networks ( Roson-Burgo et al, 2016 ). These algorithms were used to identify potential master regulators of genes that are upregulated in BM-MSCs and genes that exhibit hypomethylation (EPAS1, NFE2L1, SNAI2, STAB2, TEAD1, and TULP3) ( Sanchez-Luis et al, 2020 ). Furthermore, the gene encoding Frizzled 5, i.e., FZD5 is highly expressed in undifferentiated human MSCs, indicating that not only canonical but also non-canonical Wnt signaling is important for maintaining stemness ( Harada et al, 2020 ).…”