Deciphering gene expression profiles generated from DNA microarrays and their applications in oral medicine

Kuo, Winston Patrick; Whipple, Mark; Epstein, Joel B.; Jenssen, Tor-Kristian; Santos, Gustavo Sato dos; Ohno-Machado, Lucila; Sonis, Stephen T.

doi:10.1016/j.tripleo.2003.11.016

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…Keen research interest has also been seen in microarray analysis to reveal genetic influences on inflammation and mucosal repair, contributing to the variability in risk among individuals. 68,69…”

Section: S-18mentioning

confidence: 99%

NCCN Task Force Report: Prevention and Management of Mucositis in Cancer Care

Bensinger¹,

Schubert²,

Ang

et al. 2008

Journal of the National Comprehensive Cancer Network

169

119

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Oral mucositis (OM) has emerged as a common cause of dose delays and interruptions of cancer therapies such as multicycle chemotherapy, myeloablative chemotherapy, and radiotherapy with or without concurrent chemotherapy of head and neck cancer. Research into both preventive and management strategies has lagged behind research into the common cancer treatment–related morbidities of nausea, vomiting, and cytopenias. This disparity is related to the complex risk assessment of multifactorial patient and treatment factors and different techniques of rating mucositis. In addition, relatively few clinical trials have focused on mucositis as a specific outcome. Currently, the only effective preventive strategies include the use of palifermin to prevent OM in the setting of hematopoietic stem cell transplantation and oral cryotherapy used in conjunction with bolus 5-FU, melphalan, or edatrexate. For the most part, managing OM relies on supportive care and symptom palliation. However, OM is a common problem associated with significant patient morbidity and increased resource use. The magnitude of the problem demands innovative approaches based on expert judgment as evidence accumulates to support specific recommendations. To improve this situation, the NCCN convened a multidisciplinary task force to address key issues. This report integrates expert judgment with a review of key literature on risk assessment, prevention, and treatment strategies, and provides recommendations for the overall management of OM. (JNCCN 2008;6[Suppl 1]:S1–S21)

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Section: S-18mentioning

confidence: 99%

NCCN Task Force Report: Prevention and Management of Mucositis in Cancer Care

Bensinger¹,

Schubert²,

Ang

et al. 2008

Journal of the National Comprehensive Cancer Network

169

119

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“…Microarrays may be able to identify those genetic alterations that are more likely to determine the progression of a premalignant lesion to frank malignancy. [2526]…”

Section: Applications Of Dental Informatics In Oral Pathologymentioning

confidence: 99%

Evolution of dental informatics as a major research tool in oral pathology

Singaraju

Prasad

Singaraju

2012

J Oral Maxillofac Pathol

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Bioinformatics is a relatively new field of science that incorporates the principles of biology and computer science. It is mainly concerned with collecting, storing, and retrieving data from large databases. Ever since the successful completion of the Human Genome Project, there has been an exponential growth in the volumes of biological data that is being generated worldwide. The evolution of bioinformatics has made it possible to access these databases and apply the information for better research. One discipline that has been benefitted from the advent of bioinformatics is oral pathology. Oral pathology is a branch of dentistry which deals with the diseases of the head and neck region. Remarkable progress has been made in the diagnosis and treatment of diseases with the aid of bioinformatics. This article attempts to review the evolution and progress of dental informatics as a specialty and its applications in oral pathology.

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Current awareness on comparative and functional genomics

2004

Comp Funct Genom

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In order to keep subscribers up-to-date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly-published material on comparative and functional genomics. Each bibliography is divided into 16 sections. I Reviews & symposia; 2 General; 3 Large-scale sequencing and mapping; 4 Evolutionary genomics; 5 Comparative genomics; 6 Pathways, gene families and regulons; 7 Pharmacogenomics; 8 EST, cDNA and other clone resources; 9 Functional genomics; I0 Transcriptomics; II Proteomics; I2 Protein structural genomics; I3 Metabolomics; I4 Genomic approaches to development; I5 Technological advances; I6 Bioinformatics. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Deciphering gene expression profiles generated from DNA microarrays and their applications in oral medicine

Cited by 8 publications

References 40 publications

NCCN Task Force Report: Prevention and Management of Mucositis in Cancer Care

NCCN Task Force Report: Prevention and Management of Mucositis in Cancer Care

Evolution of dental informatics as a major research tool in oral pathology

Current awareness on comparative and functional genomics

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