Deciphering functional biomolecule potential of marine diatoms through complex network approach

Marella, Thomas Kiran; Bansal, Hina; Bhattacharjya, Raya; Himanshu, -; Parmar, Nitesh; Chaurasia, Ankur; Watanabe, Makoto M.; Bhatnagar, Amit; Tiwari, Archana

doi:10.1016/j.biortech.2021.125927

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…The significantly higher value of pristane in biofilm under HL and D (ANOVA, p<0.05) could be thus linked to MPB organisms' damage, and/or to a higher grazing activity of micromeiofaunal organisms caused by the stressing irradiance conditions (darkness or too much light). The neophytadiene was measured in some microalgae (López-Rosales et al, 2019) like marine diatoms (Marella et al, 2021). This is an isoprenoid belonging to the terpene and it can arise from the phytol which is itself a Chla degradation product (Rontani and Volkman, 2003).…”

Section: Metabolic Responses To Light Irradiance Show Lipids Central ...mentioning

confidence: 99%

The metabolites of light: Untargeted metabolomic approaches bring new clues to understand light-driven acclimation of intertidal mudflat biofilm

Doose,

Hubas

2024

Science of The Total Environment

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Section: Metabolic Responses To Light Irradiance Show Lipids Central ...mentioning

confidence: 99%

The metabolites of light: Untargeted metabolomic approaches bring new clues to understand light-driven acclimation of intertidal mudflat biofilm

Doose,

Hubas

2024

Science of The Total Environment

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Characterization of natural compounds derived from diatom C. gracilis as potential therapeutic agents: An in-silico networking and docking study

Bhattacharjya,

Bansal,

Santoshi

et al. 2024

Algal Research

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Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu

Cai

et al. 2023

Sig Transduct Target Ther

176

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Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

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Deciphering functional biomolecule potential of marine diatoms through complex network approach

Cited by 4 publications

References 44 publications

The metabolites of light: Untargeted metabolomic approaches bring new clues to understand light-driven acclimation of intertidal mudflat biofilm

The metabolites of light: Untargeted metabolomic approaches bring new clues to understand light-driven acclimation of intertidal mudflat biofilm

Characterization of natural compounds derived from diatom C. gracilis as potential therapeutic agents: An in-silico networking and docking study

Small molecule metabolites: discovery of biomarkers and therapeutic targets

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