Deciphering Deoxynybomycin Biosynthesis Reveals Fe(II)/α-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition

Hot off the press

“…Bioinformatics analysis has also been used to identify the biosynthetic gene cluster of antibacterial agents, deoxynybomycin 29 and nybomycin in Embleya hyalina NBRC 13850. 29 Various enzymes were characterised, including DnmT, a Fe( ii )/α-ketoglutarate-dependent dioxygenase that catalyses formation and decomposition of the angularly fused 4-oxazoline ring system.…”