Decidual natural killer cells: key regulators of placental development (a review)

Croy, B A; Chantakru, Sirirak; Esadeg, Souad; Ashkar, Ali A.; Wei, Qingxia

doi:10.1016/s0165-0378(02)00005-0

Cited by 127 publications

(105 citation statements)

References 59 publications

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“…Because the decidua basalis and mesometrial lymphoid aggregate of pregnancy, to some extent, represent the maternal-fetal interface and because more immunopotent cells can infiltrate into these tissues than into other parts of murine placental and decidual tissues, these results suggest that stathmin-1 ϩ DBA-lectin ϩ NK cells may be important in the modulation of maternal-fetal cross talk. 25,26 Similar results were obtained in human decidual tissue. Using CD56 as a pan-NK cell marker for human uNK cells, we found that the frequency of stathmin-1 ϩ CD56 ϩ cells was significantly higher in decidual tissues from normal early pregnancy than in those from spontaneous abortion patients ( Figure 6).…”

Section: Discussionsupporting

confidence: 77%

Reduced Stathmin-1 Expression in Natural Killer Cells Associated with Spontaneous Abortion

Lin

Shan

et al. 2011

The American Journal of Pathology

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Stathmin-1 is a small (19-kDa) regulatory phosphoprotein that integrates diverse intracellular signaling pathways. It is highly conserved among vertebrates and is associated with tubulin binding and microtubule destabilization. 1,2 Stathmin-1 has a complex phosphorylation pattern in response to various extracellular signals, in particular growth and differentiation factors. 3 Moreover, stathmin-1 phosphorylation varies during the cell cycle. 4 It has thus been thought that stathmin-1 can act as a relay integrating the activation of diverse intracellular signaling pathways and mediating the control of cell proliferation, differentiation, and other functions. 5 Stathmin-1 protein and mRNA were previously shown to be expressed in the pregnant uterus and decidualizing endometrial stromal cells in human and murine models. 6 -8 Furthermore, stathmin-1 is up-regulated in rodent uteri at the site of embryo implantation and is highly

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Section: Discussionsupporting

confidence: 77%

Reduced Stathmin-1 Expression in Natural Killer Cells Associated with Spontaneous Abortion

Lin

Shan

et al. 2011

The American Journal of Pathology

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“…Uterine receptivity is controlled by locally-acting growth factors such as natural killer (NK) cells and cytokines [35][36][37][38]. Defects in the integrity of cytokine network and an excess of NK cell activity have been implicated in implantation failure and recurrent miscarriage [38][39][40].…”

Section: Corticosteroidsmentioning

confidence: 99%

Adjuvants Therapies for Women Undergoing IVF: Is There Any Evidence of their Safety and Efficacy? An Updated Mini-Review

Fabozzi¹

2017

OGIJ

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In the last two decades a series of adjuvant therapies have been proposed to improve the success of IVF and most of them are currently prescribed even though the quality of scientific evidence supporting their efficacy in improving live birth rates after IVF is weak. The aim of this paper is to describe some of the therapies mostly used by women undergoing IVF such as dehydroepiandrosterone, testosterone, low-dose aspirin, low-molecular-weight heparin (LMWH), corticosteroids and endometrial scratching, and to assess the current evidence about their safety and efficacy. (Relative Risk (RR) 2.13; 95% CI 1.12-4.08). Similar results were obtained in subgroup analyses including randomized controlled trials and case-control studies (RR 2.57; 95% CI 1.43-4.63) and self-controlled studies (RR 3.95;). However, the effects of DHEA on oocyte retrieval, implantation, and abortion were not significant. The Cochrane review conducted in 2015 showed higher ongoing pregnancy rates or live birth rates following the pre-treatment with DHEA. Nevertheless, no benefit was observed when studies with high risk of bias were excluded [14,15]. Finally, a third meta-analysis analysing the effect of DHEA in women with DOR including a total of nine studies, four RCTs, four retrospective and one prospective concluded that clinical pregnancy rates were increased significantly in DOR patients who were pre-treated with DHEA (OR = 1.47, 95% CI: 1.09-1.99), whereas no differences were observed in the number of oocytes retrieved, the cancellation rate of IVF cycles and them is carriage rate between the cases and controls (WMD= −0.69, 95% CI: −2.18-0.81; OR = 0.74,95% CI: 0.51-1.08; OR = 0.34, 95% CI: 0.10-1.24). However, restricting the analysis to only RCTs, a non-significant difference in the clinical pregnancy rate was observed(OR = 1.08, 95% CI: 0.67-1.73) [15]. Keywords: Conclusive statementAlthough the effect of DHEA on improving ovarian response seems to be promising, there is insufficient evidence to recommend DHEA supplementation at this time. Furthermore, the long-term risk of DHEA administration remain unknown. More RCTs with large sample size are needed to obtain good quality evidence on its safety and efficacy. Testosterone (TT)Testosterone is a downstream molecule in the steroidal pathway from DHEA. It can be administered either trans-dermally or orally. Different RCTs report a beneficial effect of TT pre-treatment [16,17] and the meta-analysis from Bosdou et al. [18] analyzing both trials conducted by Massin et al. [16] and Kim et al. [17] reported that pretreatment with transdermal testosterone was associated with an increase in clinical pregnancy (risk difference (RD): +15%, 95% confidence interval (CI): +3 to +26%) and live birth rates (RD: +11%, 95% CI: +0.3 to +22%) in poor responders undergoing ovarian stimulation for IVF. A second meta-analysis conducted by also reported that testosterone-treated women achieved a significantly higher live birth rate (risk ratio, RR, 1.91, 95% CI 1.01 to 3.63), clinical pregnancy ra...

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“…These have included genetic mouse models possessing NK cell deficiencies 13 and systemic immunodepletion of NK cells using administration of antibodies to asialo GM1 during rat gestation. 14 The success of the immunodepletion approach is gestation stage-dependent and most effective when administered immediately prior to or concurrent with embryo implantation.…”

Section: Nk Cells Modulate the Timing Of Critical Events During Hemocmentioning

confidence: 99%

NK cells, hypoxia and trophoblast cell differentiation

2012

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Decidual natural killer cells: key regulators of placental development (a review)

Cited by 127 publications

References 59 publications

Reduced Stathmin-1 Expression in Natural Killer Cells Associated with Spontaneous Abortion

Reduced Stathmin-1 Expression in Natural Killer Cells Associated with Spontaneous Abortion

Adjuvants Therapies for Women Undergoing IVF: Is There Any Evidence of their Safety and Efficacy? An Updated Mini-Review

NK cells, hypoxia and trophoblast cell differentiation

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