Decidua and implantation of the embryo from a historical perspective

Damjanov, Ivan

doi:10.1387/ijdb.140075id

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…Embryo implantation is crucial for a successful pregnancy. In this process, the mature blastocyst locates, adheres and embeds into the receptive uterine endometrium [1–3]. Embryo implantation occurs during a limited period named implantation window [4,5].…”

Section: Introductionmentioning

confidence: 99%

Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway

Zhang

Ahmmed

et al. 2015

FEBS Letters

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a b s t r a c tGlycosylation plays a significant role in determining the receptivity of the uterine endometrium to embryo. Fucosyltransferase IV (FUT4) is expressed stage-specifically in the uterine endometrium of mammalians, and considered as a marker of the endometrial receptivity. Baicalin, a monomer of flavonoids, is known to have functions in improving reproduction. However, the mechanism by which baicalin regulates the expression of FUT4 in embryo-endometrium adhesion remains unclear. Our results showed that baicalin significantly increased FUT4 mRNA and protein expression levels both in human endometrial cells and mouse endometrial tissue, and consistently elevated embryo adhesion rate during implantation in vitro and embryonic implantation competence in pregnant mouse. This study suggests that baicalin facilitates endometrial reproduction via elevating FUT4 expression through Wnt/b-catenin signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway

Zhang

Ahmmed

et al. 2015

FEBS Letters

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“…Successful embryo implantation in a receptive uterine endometrium requires the decidualization of the endometrial stromal cells (ESCs) [6,7]. When embryo implantation occurs in the uterus, ESCs undergo dramatic proliferation and differentiation into transient epithelioid decidual cells [35].…”

Section: Introductionmentioning

confidence: 99%

poFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1

et al. 2019

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Background Endometrial stromal cell decidualization is critical for embryo implantation. Dysfunctional decidualization leads to implantation failure, miscarriage and even pregnancy associated disorders in subsequent pregnancy trimesters. Protein glycosylation is involved in many physiological and pathological processes. Protein O-fucosyltransferase 1 (poFUT1) is the key enzyme for the O-fucosylation of proteins. However, the role and mechanism of poFUT1 in human endometrial stromal cell decidualization remain elusive. Methods We employed immunohistochemistry to detect the level of poFUT1 in the uterine endometrium from those of the proliferative phase, secretory phase, early pregnancy women and miscarriage patients. Using human endometrial stromal cells (hESCs) and a mouse model, the underlying mechanisms of poFUT1 in decidualization was investigated. Findings The level of poFUT1 was increased in the stromal cells of the secretory phase relative to those in the proliferative phase of the menstrual cycle, and decreased in the stromal cells of miscarriage patients compared to women with healthy early pregnancies. Furthermore, we found that poFUT1 promoted hESCs decidualization. The results also demonstrated that poFUT1 increased O-fucosylation on Notch1 in hESCs, which activated Notch1 signaling pathway. Activated Notch1 (NICD), as a specific trans-factor of PRL and IGFBP1 promoters, enhanced PRL and IGFBP1 transcriptional activity, thus inducing hESCs decidualization. Interpretation Level of poFUT1 is lower in the uterine endometrium from miscarriage patients than early pregnancy women. poFUT1 is critical in endometrial decidualization by controlling the O-fucosylation on Notch1. Our findings provide a new mechanism perspective on poFUT1 in uterine decidualization that may be a useful diagnostic and therapeutic target for miscarriage. Fund National Natural Science Foundation of China (31770857, 31670810 and 31870794). Liaoning Provincial Program for Top Discipline of Basic Medical Sciences.

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DCAF13 is essential for the pathogenesis of preeclampsia through its involvement in endometrial decidualization

Yan

Rong

Zhou

et al. 2022

Molecular and Cellular Endocrinology

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Decidua and implantation of the embryo from a historical perspective

Cited by 6 publications

References 29 publications

Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway

Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway

poFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1

DCAF13 is essential for the pathogenesis of preeclampsia through its involvement in endometrial decidualization

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