Decellularized, Heparinized Small-Caliber Tissue-Engineered “Biological Tubes” for Allograft Vascular Grafts
Zhixiang Su,
Yuehao Xing,
Yonghao Xiao
et al.
Abstract:There remains a lack of small-caliber tissue-engineered
blood vessels
(TEBVs) with wide clinical use. Biotubes were developed by electrospinning
and in-body tissue architecture (iBTA) technology to prepare small-caliber
TEBVs with promising applications. Different ratios of hybrid fibers
of poly(l-lactic-co-ε-caprolactone)
(PLCL) and polyurethane (PU) were obtained by electrospinning, and
the electrospun tubes were then implanted subcutaneously in the abdominal
area of a rabbit (as an in vivo bioreactor). The … Show more
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