Decellularized extracellular matrices for tissue engineering applications

Elmashhady, Hady; Kraemer, Bruce A.; Patel, Kalpana S; Sell, Scott A.; Garg, Koyal

doi:10.1515/esp-2017-0005

Cited by 32 publications

(24 citation statements)

References 65 publications

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“…In recent years, the research in scaffold engineering has shifted from using natural polymers to using the decellularized extracellular matrix (dECM) to obtain scaffolds mimicking native ECM [ 53 ]. Methods of decellularizing tissues have been extensively reviewed [ 54 , 55 ].…”

Section: Biomaterials For Electrospinning In Tissue Engineeringmentioning

confidence: 99%

Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration

et al. 2020

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The development of smart and intelligent regenerative biomaterials for skeletal muscle tissue engineering is an ongoing challenge, owing to the requirement of achieving biomimetic systems able to communicate biological signals and thus promote optimal tissue regeneration. Electrospinning is a well-known technique to produce fibers that mimic the three dimensional microstructural arrangements, down to nanoscale and the properties of the extracellular matrix fibers. Natural and synthetic polymers are used in the electrospinning process; moreover, a blend of them provides composite materials that have demonstrated the potential advantage of supporting cell function and adhesion. Recently, the decellularized extracellular matrix (dECM), which is the noncellular component of tissue that retains relevant biological cues for cells, has been evaluated as a starting biomaterial to realize composite electrospun constructs. The properties of the electrospun systems can be further improved with innovative procedures of functionalization with biomolecules. Among the various approaches, great attention is devoted to the “click” concept in constructing a bioactive system, due to the modularity, orthogonality, and simplicity features of the “click” reactions. In this paper, we first provide an overview of current approaches that can be used to obtain biofunctional composite electrospun biomaterials. Finally, we propose a design of composite electrospun biomaterials suitable for skeletal muscle tissue regeneration.

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Section: Biomaterials For Electrospinning In Tissue Engineeringmentioning

confidence: 99%

Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration

et al. 2020

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“…Decellularized scaffolds have been widely used for skeletal muscle repair and regeneration . Recent work has also described encouraging clinical outcomes following the implantation of decellularized scaffolds in patients with VML injuries (reviewed in).…”

Section: Challenges With Existing Technologies and Future Trendsmentioning

confidence: 99%

“…Decellularized scaffolds have been widely used for skeletal muscle repair and regeneration. 167 Recent work has also described encouraging clinical outcomes following the implantation of decellularized scaffolds in patients with VML injuries (reviewed in 37 ). However, acellular ECM based therapies have a set of challenges that must be overcome in order to promote clinically relevant levels of skeletal muscle regeneration.…”

Section: Challenges With Existing Technologies and Future Trendsmentioning

confidence: 99%

Biomaterial and stem cell‐based strategies for skeletal muscle regeneration

Dunn

Talovic

Patel

et al. 2019

Journal Orthopaedic Research

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Adult skeletal muscle can regenerate effectively after mild physical or chemical insult. Muscle trauma or disease can overwhelm this innate capacity for regeneration and result in heightened inflammation and fibrotic tissue deposition resulting in loss of structure and function. Recent studies have focused on biomaterial and stem cell‐based therapies to promote skeletal muscle regeneration following injury and disease. Many stem cell populations besides satellite cells are implicated in muscle regeneration. These stem cells include but are not limited to mesenchymal stem cells, adipose‐derived stem cells, hematopoietic stem cells, pericytes, fibroadipogenic progenitors, side population cells, and CD133+ stem cells. However, several challenges associated with their isolation, availability, delivery, survival, engraftment, and differentiation have been reported in recent studies. While acellular scaffolds offer a relatively safe and potentially off‐the‐shelf solution to cell‐based therapies, they are often unable to stimulate host cell migration and activity to a level that would result in clinically meaningful regeneration of traumatized muscle. Combining stem cells and biomaterials may offer a viable therapeutic strategy that may overcome the limitations associated with these therapies when they are used in isolation. In this article, we review the stem cell populations that can stimulate muscle regeneration in vitro and in vivo. We also discuss the regenerative potential of combination therapies that utilize both stem cell and biomaterials for the treatment of skeletal muscle injury and disease. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1246–1262, 2019.

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“…Wang, Wang, Liu, & Zhang, 2016;W. Zhang et al, 2017) and decellularized tissue matrixes such as Restore™ (DePuy Orthopedics), human dermis (AlloDerm™; LifeCell Corp.), porcine urinary bladder (MatriStem™; ACell ® , Inc.), bovine pericardium (PhotoFix™, CryoLife Inc.), and porcine heart valve (Prima™ Plus; Edwards Lifesciences LLC) are presently being used in tissue engineering and regenerative medicine applications (Elmashhady, Kraemer, Patel, Sell, & Garg, 2017). Similarity in behavior to the ECM and remarkable show up of biocompatibility, biodegradability, and inherent biological functions suggests it as a suitable candidate for a variety of tissue engineering applications.…”

Section: Natural Materialsmentioning

confidence: 99%

Biomaterial aided differentiation and maturation of induced pluripotent stem cells

Velmurugan

Priya

Poornima

et al. 2018

Journal Cellular Physiology

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Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.

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Decellularized extracellular matrices for tissue engineering applications

Cited by 32 publications

References 65 publications

Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration

Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration

Biomaterial and stem cell‐based strategies for skeletal muscle regeneration

Biomaterial aided differentiation and maturation of induced pluripotent stem cells

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