Decellularized-disc based allograft and xenograft prosthesis for the long-term precise reconstruction of temporomandibular joint disc

Jiang, Nan; Chen, Haozhe; Zhang, Jie; Cao, Pinyin; Wang, Peng; Hou, Yi; Tan, Peijie; Sun, Jialin; Li, Zhen

doi:10.1016/j.actbio.2023.01.042

Cited by 7 publications

(5 citation statements)

References 71 publications

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“…It might be difficult to control TMJA [23]. In investigations, many treatment strategies for TMJA have been developed [24]. The most common surgical procedures are hemi or complete joint replacement, gap arthroplasty, and interposition arthroplasty [25,26].…”

Section: Discussionmentioning

confidence: 99%

Frequency and Pattern of Presentation of Different Types of TMJ Ankylosis in Patients Presenting to Nisthar Institute of Dentistry, Multan

Muntaha¹,

Fishan²,

Nazir³

et al. 2023

PJMHS

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Objective: Temporomandibular joint (TMJ) ankylosis is a disorder where the temporomandibular joint, which joins the lower jaw to the skull, fuses or becomes "ankylosed." This can result in pain, difficulty opening the mouth, and other symptoms as a result of an injury, infection, or other factors. TMJ ankylosis can be treated with surgery, medication, and physical therapy. Arthrocentesis, arthroscopy, and open-joint surgery are surgical options. This retrospective study sought to examine the temporomandibular joint (TMJ) ankylosis pattern and its underlying causes in patients who had received treatment at Multan's Nisthar Institute of Dentistry. Methods: From 2018 to 2022, Nishtar Institute of Dentistry, Multan treated patients with temporomandibular joint ankylosis for 4 years. All patients whose records were sufficiently complete were analyzed in this research. Demographic data, the cause and pattern of ankylosis, the interval between the injury and therapy, simultaneous facial lacerations, remnant dislocation, a previous pedicle method, mouth opening prior to and following ankylosis treatment, health issues, the follow-up period, and physical therapy prior to and following ankylosis treatment are all included in the information. Results: Out of 32 patients with 45 afflicted joints and a mean ± standard deviation age of 29.90 ± 17.08 years, 25 (78%) occurrences of temporomandibular joint ankylosis were attributed to trauma (mainly between 20 and 29 years old). Bilateral participation outweighed unilateral involvement 13 to 9 and males outnumbered women 23 to 9. Restricted mouth opening was the patient's primary complaint the majority of the time (n=24, or 75%). The temporomandibular joint was completely ankylosed in 24 individuals. Prior to surgery, the mean maximum mouth openness was 0.95 ± 0.45 cm; however, it dramatically elevated to 4.50 ± 0.50 cm (p-value 0.001) following surgery. Conclusions: This research found that the most frequent complication of temporomandibular joint ankylosis among the participants it looked at was trauma. The patient's limited mouth opening was their most frequent primary complaint. Additionally, this study's findings revealed that men are more likely than women to develop TMJ ankylosis and that these patients' TMJ functions can be significantly improved through the surgery. Keywords: temporomandibular, TMJ, temporomandibular joint

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Section: Discussionmentioning

confidence: 99%

Frequency and Pattern of Presentation of Different Types of TMJ Ankylosis in Patients Presenting to Nisthar Institute of Dentistry, Multan

Muntaha¹,

Fishan²,

Nazir³

et al. 2023

PJMHS

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“…In clinical practice, we generally use temporalis myofascial flap and abdominal fat graft to replace the buffering function of the articular disc [ 37 , 38 ]. Relevant researches on artificial TMJ disc have achieved satisfactory results in animal models [ 40 – 42 ]. However, no clinical study has been performed, which is one of the research directions in the future.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of the temporomandibular joint using a vascularized medial femoral condyle osteocartilaginous flap: an experimental investigation in miniature pigs

Lin,

Chen,

Xia

et al. 2023

BMC Oral Health

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Background Reconstruction of the temporomandibular joint (TMJ) is a significant challenge in maxillofacial surgery. A vascularized medial femoral condyle (MFC) osteocartilaginous flap is a good choice for TMJ reconstruction. In this study, we evaluated the radiographic and histological changes of MFC after TMJ reconstruction. Methods A ramus-condyle unit (RCU) defect was created unilaterally in five adult male Bama miniature pigs. The ipsilateral vascularized MFC osteocartilaginous flap was used to reconstruct the TMJ, and the non-operative sides served as controls. Multislice spiral computed tomography (CT) was performed preoperatively, immediately postoperatively, and at two weeks, three months, and six months postoperatively. Three animals were euthanized at 6 months postoperatively. Their reconstructed condyles, natural condyles and the MFCs on the opposite side were collected and subjected to µCT and histological evaluation. Results In the miniature pigs, the vascularized MFC osteocartilaginous flap was fused to the mandible, thus restoring the structure and function of the RCU. The postoperative radiographic changes and histological results showed that the reconstructed condyle was remodeled toward the natural condyle, forming a similar structure, which was significantly different from the MFC. Conclusions In miniature pigs, the RCU can be successfully reconstructed by vascularized osteocartilaginous MFC flap. The reconstructed condyle had almost the same appearance and histological characteristics as the natural condyle.

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“…These xenograft discs were functional and could stabilize the goats’ TMJs for 20 weeks post-operative. This shows the therapeutic potential of TMJ disc allografts and xenografts in the management of TMJ disc degenerative disorders [ Jiang et al,2023 ]. Hopefully soon, tissue engineering scientists can provide precise human TMJ models by employing bone inductive scaffolds and stem cells with potentials to differentiate into TMJ disc fibro-chondrocytes.…”

Section: Oral and Maxillofacial Engineered Tissuesmentioning

confidence: 99%

Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction

Maria,

Heram,

Tran

2024

The Saudi Dental Journal

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Decellularized-disc based allograft and xenograft prosthesis for the long-term precise reconstruction of temporomandibular joint disc

Cited by 7 publications

References 71 publications

Frequency and Pattern of Presentation of Different Types of TMJ Ankylosis in Patients Presenting to Nisthar Institute of Dentistry, Multan

Frequency and Pattern of Presentation of Different Types of TMJ Ankylosis in Patients Presenting to Nisthar Institute of Dentistry, Multan

Reconstruction of the temporomandibular joint using a vascularized medial femoral condyle osteocartilaginous flap: an experimental investigation in miniature pigs

Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction

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