Decellularized biohybrid nerve promotes motor axon projections
Abijeet Singh Mehta,
Sophia L. Zhang,
Xinran Xie
et al.
Abstract:Developing nerve grafts with intact mesostructures, superior conductivity, minimal immunogenicity, and improved tissue integration is essential for the treatment and restoration of neurological dysfunctions. A key factor is promoting directed axon growth into the grafts. To achieve this, we developed biohybrid nerves using decellularized rat sciatic nerve modified by in situ polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). We compared nine biohybrid nerves with varying polymerization conditions and … Show more
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