Decellularization Strategies for Regenerative Medicine in Cardiovascular Diseases and Other Severe Problems Within the Body: From Processing Techniques to Applications

Cesur, Nevra Pelin; Laçin, Nelisa Türkoğlu

doi:10.1007/978-3-030-92090-6_46-1

Handbook of the Extracellular Matrix 2023

DOI: 10.1007/978-3-030-92090-6_46-1

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Decellularization Strategies for Regenerative Medicine in Cardiovascular Diseases and Other Severe Problems Within the Body: From Processing Techniques to Applications

Nevra Pelin Cesur,

Nelisa Türkoğlu Laçin

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2024

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Cited by 1 publication

References 86 publications

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Fabrication of bacterial cellulose/PVP nanofiber composites by electrospinning

Cesur,

Zad Ghaffari Vahdat,

Türkoğlu Laçin

2024

Biopolymers

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This study aimed to address a significant challenge in the application of bacterial cellulose (BC) within tissue engineering and regenerative medicine by tackling its inherent insolubility in water and organic solvents. Our team introduced a groundbreaking approach by utilizing zinc sulfate (ZnSO4) as a solvent to render BC soluble, a novel contribution to the literature. Subsequently, the obtained soluble BC was combined with varying concentrations of polyvinylpyrrolidone (PVP). Notably, we pioneered the fabrication of BC/PVP composite scaffolds with customizable fiber surface morphology and regulated degradation rates through the electrospun technique. Several key parameters, such as PVP concentration (8%, 15%, 12%, and 20% w/v), applied voltage (22, 15, and 12 kV), and a fixed nozzle‐collector distance of 10 cm with a flow rate of 0.9 mL/h, were systematically evaluated so as to find the optimum parameter created BC/PVP product with electrospun. For electrospun BC/PVP products, a voltage of 12 kV was found to be optimal. Intriguingly, our findings revealed enhanced cell adhesion and proliferation in BC/PVP electrospun products compared with using PVP membranes alone. Specifically, cell viability for PVP and PVP/BC electrospun products was determined as 50.73% and 79.95%, respectively. In terms of thermal properties, the BC/PVP electrospun product exhibited a mass loss of 82.6% at 380°C, while PVP alone experienced 90.2% mass loss at around 280°C. Furthermore, the protein adhesion capacities were measured at 62.3 ± 1.2 μg for PVP and 99.4 ± 2 μg for BC/PVP electrospun products, whereas product showed no biodegradation over 28 days and had notable water retention capacity. In conclusion, our research not only successfully attained nanofiber morphology but also showcased enhanced cell attachment and proliferation on the BC/PVP electrospun product.

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Fabrication of bacterial cellulose/PVP nanofiber composites by electrospinning

Cesur,

Zad Ghaffari Vahdat,

Türkoğlu Laçin

2024

Biopolymers

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Decellularization Strategies for Regenerative Medicine in Cardiovascular Diseases and Other Severe Problems Within the Body: From Processing Techniques to Applications

Cited by 1 publication

References 86 publications

Fabrication of bacterial cellulose/PVP nanofiber composites by electrospinning

Fabrication of bacterial cellulose/PVP nanofiber composites by electrospinning

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