Decellularization and Recellularization Methods for Avian Lungs: An Alternative Approach for Use in Pulmonary Therapeutics

Tanneberger, Alicia E.; Weiss, Daniel J.; Uriarte, Juan J.

doi:10.1007/978-1-0716-1811-0_33

Cited by 1 publication

(4 citation statements)

References 18 publications

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“…The immune response is mainly directed against the proteins and lipids of cell membranes; thus, cell extraction from tissue is a promising method to avoid the creation of a post-transplant immune response in the body of the recipient [ 4 , 12 , 13 , 14 , 15 , 16 ]. The removal of cellular components should minimize the immunologically induced inflammatory process, which may weaken the biodegradation process of the transplanted bioprosthesis [ 15 ]. The procedure of removing cells from allogeneic human dermis results in a cell-free, non-immunogenic matrix composed of extracellular matrix (ECM) elements that can be re-inhabited by autologous cells.…”

Section: Resultsmentioning

confidence: 99%

“…The procedure of removing cells from allogeneic human dermis results in a cell-free, non-immunogenic matrix composed of extracellular matrix (ECM) elements that can be re-inhabited by autologous cells. Such cell-free dermal matrices (ADMs) can also stimulate natural regenerative and reconstructive mechanisms [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…Based on the results of numerous studies, it has also been shown that cell-free ECM scaffolds are able to propagate and support the growth and differentiation of many types of cells in vitro and induce constructive tissue remodelling processes after in vivo transplantation [ 7 , 8 , 9 , 10 , 11 ]. Thus, the use of three-dimensional ECM scaffolds obtained from tissues or whole organs that have undergone cell removal procedures is an increasingly used strategy of regenerative medicine and tissue engineering [ 4 , 5 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Application of Acellular Dermal Matrix in Gynaecology—A Current Review

Skowronek

Łabuś

Stojko

et al. 2022

JCM

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The aim of our study is to draw attention to the multitude of applications of acellular dermal matrix (ADM) in the surgical treatment of urogynaecological disorders, such as reduction in the reproductive organs, and in reconstructive gynaecology. Despite the existence of numerous operational methods and materials, the effectiveness of transvaginal operation is still insufficient. Native tissue operations are often not durable enough, while operations with synthetic materials have numerous side effects, such as infections, hematomas, vaginal erosion, or dyspareunia. Hence, the search continues for a different material with a better efficacy and safety profile than those previously mentioned. It seems that ADM can meet these requirements and be a useful material for urogynaecological surgery. Key words related to the usage of ADM in gynaecological reconstructive surgery were used to search relevant databases (NCBI MedLine, Clinical Key, Clinicaltrials.gov). This manuscript is based on 43 literature sources, 28 (65.11%) of which were released after 2016. Older sources are cited for the purpose of presenting basic science, or other important issues related to the manuscript. ADM seems to be an ideal material for urogynaecological and reconstructive surgery. It has high durability, and thus high effectiveness. Moreover, it does not have the side effects typical for synthetic materials. There are no reports of material rejection, erosion or dyspareunia directly related to the presence of the mesh. Due to the difficulties in obtaining ADM and the need to perform additional tests, this material is not common in routine clinical practice. Therefore, the number of cases and the size of the research groups are insufficient to clearly define the potential of mesh from biological tissue. However, the results are so promising that it is worth considering a wider introduction to the use of this material. Our hope is that increasing clinicians’ awareness of this topic will lead to more studies comparing methods using native tissues or synthetic materials and those using ADM.

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