Deceleration of Age-Related Aortic Stiffening in a Population With High Longevity Rates

Pietri, P; Vlachopoulos, Charalambos; Chrysοhoou, Christina; Lazaros, George; Masoura, Konstantina; Ioakeimidis, N.; Tousoulis, Dimitris; Stefanadis, Christodoulos

doi:10.1016/j.jacc.2015.07.070

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…Previously, the IKARIA study in Greece proposed that PWV values in subjects living in a district with greater longevity may be lower than the expected European mean; however, that study did not compare PWV values to those of subjects living in a district with a shorter life span. 12 In the present study, baPWV values were also higher in people residing in a district with a relatively high prevalence of CVD (Wakayama) than in those residing in a district with a relatively low prevalence of CVD (Nagano), 4 especially in the subgroup of elderly subjects aged ≥70 years.…”

Section: Discussionsupporting

confidence: 51%

District Differences in the Measured Values of Arterial Stiffness in Japan

Miyai

Uchiba²,

Tomiyama

et al. 2021

Circ Rep

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Background: In Japan, district differences in the prevalence of cardiovascular disease (CVD) are well-known. This study examined district differences in Japan in measured values of arterial stiffness, an independent risk factor for CVD. Methods and Results: Local residents participating in health checkups conducted in the Wakayama (n=461) and Nagano (n=186) prefectures in 2018 were recruited to the study. Brachial-ankle pulse wave velocity (baPWV) was evaluated as an index of arterial stiffness. After multivariate adjustment, baPWV was significantly higher in the Wakayama than Nagano district in subjects aged ≥70 years (mean [±SE] 1,912±25 vs. 1,763±30 cm/s; P<0.01), but not in subjects aged <70 years. Multivariate linear regression analysis demonstrated that the Wakayama/Nagano district difference was significantly (P<0.01) associated with baPWV. Conclusions: District differences were observed in the measured values of arterial stiffness in Wakayama and Nagano. The Wakayama and Nagano prefectures are representative areas with a relatively high and relatively low prevalence of CVD, respectively, in Japan. Therefore, based on the results of the present study, we propose to conduct a study to examine whether district differences in arterial stiffness underlie district differences in the prevalence of CVD.

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Section: Discussionsupporting

confidence: 51%

District Differences in the Measured Values of Arterial Stiffness in Japan

Miyai

Uchiba²,

Tomiyama

et al. 2021

Circ Rep

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“…Furthermore, in participants in IKARIA study, aortic stiffness increases gradually with age; however, in people above the age 50 years old, aortic stiffening seems to be decelerated as it is more preserved than reference values [26]. This finding may be attributed to either a favorable hemodynamic pattern or to beneficial genetic and metabolic backgrounds that are implicated in the process of both longevity and aortic stiffness, and this also reflected in preserved muscle mass [26].…”

Section: Discussionmentioning

confidence: 91%

“…The independently inverse association between arterial stiffness and SMM, in contrast with the positive association with adiposity has been previously reported [25]. It is well known that aging causes progressive stiffness, dilatation, and lengthening of the arteries; thus, low arterial distensibility has long been recognized as an indicator of atherosclerosis and future cardiovascular events [26]. Furthermore, in participants in IKARIA study, aortic stiffness increases gradually with age; however, in people above the age 50 years old, aortic stiffening seems to be decelerated as it is more preserved than reference values [26].…”

Section: Discussionmentioning

confidence: 93%

“…It is well known that aging causes progressive stiffness, dilatation, and lengthening of the arteries; thus, low arterial distensibility has long been recognized as an indicator of atherosclerosis and future cardiovascular events [26]. Furthermore, in participants in IKARIA study, aortic stiffness increases gradually with age; however, in people above the age 50 years old, aortic stiffening seems to be decelerated as it is more preserved than reference values [26]. This finding may be attributed to either a favorable hemodynamic pattern or to beneficial genetic and metabolic backgrounds that are implicated in the process of both longevity and aortic stiffness, and this also reflected in preserved muscle mass [26].…”

Section: Discussionmentioning

confidence: 99%

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Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors

et al. 2020

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The sex-specific effect of skeletal muscle mass (SMM) index (SMI) on 4-year first fatal/non-fatal cardiovascular disease (CVD) event in free-of-disease individuals was examined. In 2009, n = 1411 inhabitants (mean age = 64(12)) from Ikaria were selected. Follow-up was performed in 2013. SMI was created to reflect SMM through appendicular skeletal muscle mass (indirectly calculated through formulas) divided by body mass index (BMI). Fifteen and six tenths percent of participants exhibited CVD (19.8% in men/12% in women, p = 0.002). Significant U-shape trends were observed in participants >65 years old and women irrespective to age confirmed through multi-adjusted Cox regression analysis; in age >65 years, Hazard Ratio (HR)(2nd vs. 1st SMI tertile) = 0.80, 95% Confidence Interval (95%CI) (0.45, 0.96) and in women HR(2nd vs. 1st SMI tertile) = 0.71, 95% CI (0.33, 0.95), while, as for the 3rd SMI tertile, no significant trends were observed. Mediation analysis revealed that mediators of the aforementioned associations in men were the arterial distensibility and total testosterone, while, in women, inflammation, insulin resistance, and arterial distensibility. High SMM accompanied by obesity may not guarantee lower CVD risk. Specific cardiometabolic factors seem to explain this need for balance between lean and fat mass.

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“…Telomere attrition (expressed in WCCs) can serve as a biomarker of the cumulative oxidative stress and inflammation induced by smoking and, consequently, show the pace of biological ageing. 42–44 …”

Section: Introductionmentioning

confidence: 99%

Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study

et al. 2016

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IntroductionThe process of population ageing that is occurring in developed societies represents a major challenge for the health system. The aim of this study is to analyse factors that have an influence on early vascular ageing (EVA), estimated by carotid-femoral pulse wave velocity (cf-PWV) and Cardio Ankle Vascular Index (CAVI), and to determine differences by gender in a Spanish population.Methods and analysisAn observational, descriptive, cross-sectional study.Study populationFrom the population assigned to the participating healthcare centres, a cluster random sampling stratified by age and gender will be performed to obtain 500 participants aged between 35 and 75. Those who meet the inclusion criteria and give written informed consent will be included in the study.MeasurementsMain dependent variables: cf-PWV determined using the SphygmoCor System and CAVI estimated using VASERA. Secondary dependent variables: telomere length, carotid intima-media thickness, central and peripheral augmentation index, ankle-brachial pulse wave velocity, ankle-brachial index, retinal arteriovenous index, and renal and cardiac organ damage. Independent variables: lifestyles (physical activity, adherence to the Mediterranean diet, alcohol and tobacco consumption); psychological factors (depression, anxiety and chronic stress); inflammatory factors and oxidative stress.Ethics and disseminationThe study has been approved by the clinical research ethics committee of the healthcare area of Salamanca. All study participants will sign an informed consent form agreeing to participate in the study in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow the understanding of the relationship of the different influencing factors and their relative weight in the development of EVA. At least 5 publications in first-quartile scientific journals are planned.Trial registration numberNCT02623894; Pre-results.

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Deceleration of Age-Related Aortic Stiffening in a Population With High Longevity Rates

Cited by 13 publications

References 4 publications

District Differences in the Measured Values of Arterial Stiffness in Japan

District Differences in the Measured Values of Arterial Stiffness in Japan

Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors

Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study

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