Decay of haemoglobin a1c upon return to normoglycaemia

Chantelau, Ernst

doi:10.1007/bf00402556

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1993

2009

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Cited by 6 publications

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“…(1994) have recently discussed the effects that short lasting increases or long lasting decreases may exert on HbAlc concentrations. Particular attention has been drawn to the kinetics of the decay of HbAlc in response to a decrease in blood glucose (Chantelau, 1992;Zielke et al, 1993;Goldstein et al, 1994). HbAlc is assumed to decline at maximum speed over a large range provided a previously hyperglycemic individual abruptly lowers his/her blood glucose and keeps it Diseases and Nutrition, Heinrich-Heine-University of of total hemoglobin).…”

Section: Introductionmentioning

confidence: 98%

Observations on the decay of glycated hemoglobin HbA1c in diabetic patients

Me¹

2009

Exp Clin Endocrinol Diabetes

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In 44 diabetic patients, who within 7 days lowered their average glycemia by 140 to 220 mg % and kept it at this level over a mean of 36 days, HbA1c was measured repeatedly by HPLC (normal range 4.2-5.6% of total hemoglobin). Thereby, the maximum decay rate of HbA1c could be observed in vivo as being 0.1% per day which is consistent with previous theoretical considerations by other authors. Some clinical implications that this finding may have for diabetic patients are being discussed.

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Section: Introductionmentioning

confidence: 98%