Decarboxylative amination of benzoic acids bearing electron-donating substituents and nonactivated amines

Abstract

Efficient methods for decarboxylative activation of benzoic acids into great valuable products are highly sought after. Here we report a highly desirable and straightforward decarboxylative amination of readily available benzoic...

De novo three-component synthesis of meta-substituted anilines

“…Likewise, the selectivity issue arises when direct meta -amination of arenes is attempted. 6 A tactical solution to the selectivity problem could be seen in targeting the meta -position through preliminary functionalization of an arene parent molecule with a directing group 7 or another functionality suitable for follow-up amination, 8–10 yet it might demand numerous functional group manipulations. In turn, classical protocols for accessing meta -substituted anilines through nitroarenes often require harsh conditions affecting sensitive functional groups.…”

Decarboxylative Iodination and Suzuki-Miyaura Coupling Reactions to Access Chiral 3,3′-Diaryl-1,1′-bi-2-naphthols

“…Later, their method was successfully employed for the cross-coupling reactions (Figure . Method III) . The traditional way of introduction of halogens at the 3,3′-position in BINOL requires sensitive reagents such as chloromethyl methyl ether and n -BuLi, requiring non-aqueous condition .…”