Decalogue for the selection of oral antibiotics for lower respiratory tract infections

Barberán, José; Linares, Mariano; Molero, José; Rodríguez-González-Moro, José Miguel; Salavert, Miguel; Castillo, Juan González del

doi:10.37201/req/172.2021

Cited by 5 publications

(5 citation statements)

References 63 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Six randomized comparative studies in patients with lower respiratory tract infections, 5 of which were large (enrolment of more than 200 patients) and double-blind, examined the efficacy and safety of cefpodoxime. Cefpodoxime 200mg administered twice daily for 5 to 10 days was similar in clinical and bacteriological efficacy [14] . Additionally, a dosage equivalent to 100mg or 200mg of cefpodoxime twice daily was similar in clinical and bacteriological efficacy in the treatment of bronchitis (acute or AECB).…”

Section: Discussionmentioning

confidence: 83%

Prescription trends on the preference of antibiotics for the management of respiratory tract infections in India

2024

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

Background: Respiratory tract infections are a major cause of morbidity and mortality in developing countries. Irrational prescribing of various drugs for respiratory diseases are common practice worldwide. Considering this scenario, the present study was undertaken to analyse recent prescribing trends in the management of Respiratory Tract Infections (RTIs). Methodology: This study collected data from a multiple-response questionnaire-based survey among 442 clinicians via email or an online survey platform. The questionnaire focused on the prevalence, symptoms, causes, clinical characteristics, management of RTI, and the usage of respiratory medications in clinical practice. Results: About 47% of respondents said that 11-30% of their patients need more than one antibiotic for RTI. 53% of respondents observed pharyngitis/ tonsillitis as the most common indication of RTI. Close to half of the respondents (45%) prescribe antibiotics to 50-75% of their patients. Nearly half of the respondents (48%) said that cefpodoxime was the most common antibiotic they prescribe regularly in their practice. 37% of respondents prefer cefpodoxime in bacterial tonsillopharyngitis while 21% prefer amoxicillin + clavulanic acid and azithromycin. 44% of respondents prefer cefpodoxime in AECB (acute bacterial exacerbation of chronic bronchitis) while 15% prefer amoxicillin + clavulanic acid and only 10% prefer azithromycin. 51% of respondents prefer cefpodoxime in bacterial rhino sinusitis (acute bacterial exacerbation of chronic bronchitis). Conclusion:The prescribing patterns for the management of RTIs in the clinical practice were inconsistent with current guidelines. Strict adherence to guidelines must be ensured and antibiotic prescribing for RTIs should be discouraged.

show abstract

Section: Discussionmentioning

confidence: 83%

Prescription trends on the preference of antibiotics for the management of respiratory tract infections in India

2024

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

show abstract

“…Pneumonia can be caused by various microorganisms: bacteria, viruses, and fungi. Textbooks and elaborations still state that the most common bacterial aetiological factors include Streptococcus pneumoniae and type b Haemophilus influenzae (Hib) [ 8 , 14 , 29 , 37 , 38 , 39 ]. The aetiological factor of pneumonia is not always identified.…”

Section: Discussionmentioning

confidence: 99%

Change for the Better: Severe Pneumonia at the Emergency Department

2022

View full text Add to dashboard Cite

This is a single-centre observational study of adult patients with severe pneumonia requiring hospitalization conducted at the emergency department. During the observation period (94 weeks), 398 patients were diagnosed with severe pneumonia and required further treatment at the hospital. The median age of patients was 73 years. About 65% of patients had at least one chronic comorbidity. Almost 30% of patients had cardiovascular disorders, and 13% had diabetes mellitus. The average Emergency Department length of stay was 3.56 days. The average length of hospitalization was 15.8 days. Overall, 94% of patients treated for pneumonia received a beta-lactam antibiotic. The median time from ED admission to the administration of the first dose of antimicrobial agent was less than 6 h. Microbiology test samples were obtained from 48.7% patients. Gram-positive cocci were isolated most commonly (52.9%) from blood samples. Biological material from the lower respiratory tract was collected from 8.3% of patients, and from 47.2% of positive samples, fungi were cultured. The urine samples were obtained from 35.9% patients, and Gram-negative rods (76%) were isolated most commonly. Overall, 16.1% of patients died during the hospitalization. The mean age of patients who died was 79 years. This observational study is the first single-centre study conducted as part of the Polish Emergency Department Research Organization (PEDRO) project. It aims to provide up-to-date information about patients with pneumonia in order to improve medical care and develop local diagnostic and therapeutic recommendations.

show abstract

“…In contrast, frequency of carbapenemase production by PAER is lower [140], previous antibiotic pressure in-fixime, almost 70% of isolates, this antibiotic is considered inappropriate. Finally, cefuroxime in usual dosage (500 mg twice a day) does not reach enough serum concentration to be active against S. pneumoniae [61,[116][117][118][119].…”

Section: Therapeutic Optimisation In Community-acquired Pneumoniamentioning

confidence: 99%

Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023

Rodríguez-Leal,

González-Corralejo,

Candel

et al. 2024

Rev Esp Quimioter

View full text Add to dashboard Cite

Pneumonia is a multifaceted illness with a wide range of clinical manifestations, degree of severity and multiple potential causing microorganisms. Despite the intensive research of recent decades, community-acquired pneumonia remains the third-highest cause of mortality in developed countries and the first due to infections; and hospital-acquired pneumonia is the main cause of death from nosocomial infection in critically ill patients. Guidelines for management of this disease are available world wide, but there are questions which generate controversy, and the latest advances make it difficult to stay them up to date. A multidisciplinary approach can overcome these limitations and can also aid to improve clinical results. Spanish medical societies involved in diagnosis and treatment of pneumonia have made a collaborative effort to actualize and integrate last expertise about this infection. The aim of this paper is to reflect this knowledge, communicated in Fifth Pneumonia Day in Spain. It reviews the most important questions about this disorder, such as microbiological diagnosis, advances in antibiotic and sequential therapy, management of beta-lactam allergic patient, preventive measures, management of unusual or multi-resistant microorganisms and adjuvant or advanced therapies in Intensive Care Unit.

show abstract

Decalogue for the selection of oral antibiotics for lower respiratory tract infections

Cited by 5 publications

References 63 publications

Prescription trends on the preference of antibiotics for the management of respiratory tract infections in India

Prescription trends on the preference of antibiotics for the management of respiratory tract infections in India

Change for the Better: Severe Pneumonia at the Emergency Department

Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023

Contact Info

Product

Resources

About