Decaging-to-labeling: Development and investigation of quinone methide warhead for protein labeling

Proximitomics by Reactive Species

“…Conversely, electron-donating groups facilitate the self-elimination of the QM precursor but decelerate the formation of QM adducts. Recently, the Chen group evaluated the reactivity of a panel of QM structures and found a better warhead with improved protein labeling intensity . Further screening is needed to identify new QM structures for proximity labeling on different scales.…”

“…Recently, the Chen group evaluated the reactivity of a panel of QM structures and found a better warhead with improved protein labeling intensity. 94 Further screening is needed to identify new QM structures for proximity labeling on different scales.…”